Evidence map›Paper›PMID 31574796›Full record

ArticleMedicine2019

Evaluation of halitosis in adult patients after treatment with photodynamic therapy associated with periodontal treatment: Protocol for a randomized, controlled, single-blinded trial with 3-month follow up.

Sergio Dos Santos Romero, Tânia Oppido Schalch, Katia Llanos do Vale, Ellen Sayuri Ando, Marcia Pinto Alves Mayer, Joanna Paula Gaba Feniar, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Lara Jansiski Motta, Renata Matalon Negreiros and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03996915 (Evaluation of Halitosis in Adult Patients After Treatment With Photodynamic Therapy Associated With Periodontal Treatment), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03996915 nacompletednot on this map

Evaluation of Halitosis in Adult Patients After Treatment With Photodynamic Therapy Associated With Periodontal Treatment: Protocol for a Randomized, Controlled Single Blinded Trial With 3-month Follow up

TypeinterventionalSponsorUniversity of Nove de JulhoRan2019 to 2019Enrolled40ConditionsHalitosisArmsPdt Photodynamic Therapy, tongue scrapper
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sergio Dos Santos RomeroPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Tânia Oppido SchalchPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Katia Llanos do ValePostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Ellen Sayuri AndoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo.
Marcia Pinto Alves MayerDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo.
Joanna Paula Gaba FeniarAssistant Professor of Specialization in Oral Maxillofacial Surgery and Traumatology at Fundecto - FFO, School of Dentistry - FOUSP, University of São Paulo, São Paulo, Brazil.
Kristianne Porta Santos FernandesPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Sandra Kalil BussadoriPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Lara Jansiski MottaPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Renata Matalon NegreirosPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Anna Carolina Ratto Tempestini HorlianaPostgraduate program in Biophotonics Applied to Health Sciences, University Nove de Julho, UNINOVE.
Universidade Nove de Julho · BRInstitute of Biomedical Science · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleHalitosis is an unpleasant odor that emanates from the mouth. Studies show halitosis returns in a week, after treatment with PDT. Probably, bacteria living in the periodontal sulcus could recolonize the dorsum of the tongue. Until nowadays, there are no study in adult population that associates halitosis and periodontal treatment with follow-up evaluation. The aim of this randomized, controlled, single-blinded clinical trial is to treat oral halitosis in healthy adults with photodynamic therapy (PDT), associated with periodontal treatment and follow them up for 3 months. PATIENT CONCERNS:: the concerns assessments will be done over the study using anamnesis interviews and specific questionnaire. DIAGNOSES:: halitosis will be evaluated by OralChroma.

interventionsThe participants (n = 40) with halitosis will be randomized into 2 groups: G1-treatment with PDT (n = 20) or G2-cleaning of the tongue with a tongue scraper (n = 20). OUTCOMES: Halitosis will be evaluated by measuring volatile sulfur compounds using gas chromatography. After the treatments, a second evaluation will be performed, along with a microbiological analysis (RT-PCR) for the identification of the bacteria T. denticola. The assessment of halitosis and the microbiological analysis will be repeated. After that, patients will receive periodontal treatment. The participants will return after 1 week and 3 months for an additional evaluation. Quality of life will be measured by Oral Health Impact Profile questionnaire (OHIP-14). LESSONS: This protocol will determine the effectiveness of phototherapy regarding the reduction of halitosis in adults. clinicaltrials.gov NCT03996915. ETHICS AND DISSEMINATION: This protocol received approval from the Human Research Ethics Committee of Universidade Nove de Julho (certificate number: 3.257.104). The data will be published in a peer-reviewed periodical.

Indexed as

PhotochemotherapyChromatography, GasFollow-Up StudiesHalitosisHumansMiddle AgedOral HygienePeriodontal DiseasesPhotosensitizing AgentsRandomized Controlled Trials as TopicRecurrenceSingle-Blind MethodTreatment OutcomeTreponema denticolaPhotosensitizing Agents

Identifiers

PMID31574796
PMCPMC6775352
OpenAlexW2976478648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.