Evidence map›Paper›PMID 31574531›Full record

ArticlePediatric research2020

Higher chocolate intake is associated with longer telomere length among adolescents.

Li Chen, Haidong Zhu, Bernard Gutin, Howard D Sesso, Yanbin Dong

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li ChenGeorgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Haidong ZhuGeorgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Bernard GutinGeorgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Howard D SessoDivision of Preventive, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Yanbin DongGeorgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. YDONG@augusta.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChocolate intake has shown cardiometabolic health benefits. Whether chocolate has any effect on cellular aging remains unknown. We aimed to test the hypothesis that higher chocolate intake is associated with longer leukocyte telomere length (LTL) in adolescents.

methodsA total of 660 adolescents (aged 14-18 years) were included in the analysis. The chocolate intake was assessed by 7-day, 24-h dietary recalls and split into three groups, which were none, <2 servings/week, and 2 servings/week or more. LTL (T/S ratio) was determined by a modified quantitative polymerase chain reaction-based assay.

resultsAmong the 660 adolescents, 58% did not take any chocolate, 25% consumed <2 servings/week, and 17% consumed ≥2 servings/week. Compared to non-consumers, adolescents who consumed chocolate of ≥2 servings/week had 0.27 standard deviation (SD) longer LTL (p = 0.014). Higher chocolate consumption was associated with increased apolipoprotein A1 (ApoA1) (p = 0.038) and ApoA1/high-density lipoprotein (HDL) (p = 0.046). Moreover, higher ApoA1/HDL levels were correlated with longer LTL (p = 0.026).

conclusionAdolescents who consume 2 servings/week or more of chocolate candy have longer LTL compared with non-consumers, and ApoA1/HDL pathway may be involved in this relationship.

Indexed as

Adolescent BehaviorChocolateFeeding BehaviorTelomere HomeostasisAdolescentAge FactorsApolipoprotein A-IBiomarkersCross-Sectional StudiesFemaleHumansLipoproteins, HDLMaleServing SizeAPOA1 protein, humanApolipoprotein A-IBiomarkersLipoproteins, HDL

Identifiers

PMID31574531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.