Evidence map›Paper›PMID 31574322›Full record

ArticleNeuroImage2020

Individualized functional networks reconfigure with cognitive state.

Mehraveh Salehi, Amin Karbasi, Daniel S Barron, Dustin Scheinost, R Todd Constable

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Geometric influences on the regional organization of the mammalian brain.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Lateralized Functional Connectivity of the Sensorimotor Cortex and its Variations During Complex Visuomotor Tasks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Masked features of task states found in individual brain networks.Cerebral cortex (New York, N.Y. : 1991) · 2023
    Article
  20. Cingulo-Opercular Subnetworks Motivate Frontoparietal Subnetworks during Distinct Cognitive Control Demands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mehraveh SalehiDepartment of Electrical Engineering, Yale University, New Haven, CT, 06511, USA; Yale Institute for Network Science (YINS), Yale University, New Haven, CT, 06511, USA. Electronic address: mehraveh.salehi@yale.edu.
Amin KarbasiDepartment of Electrical Engineering, Yale University, New Haven, CT, 06511, USA; Yale Institute for Network Science (YINS), Yale University, New Haven, CT, 06511, USA.
Daniel S BarronDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06520, USA.
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA.
R Todd ConstableDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, 06520, USA; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, 06520, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 06520, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
Understanding evoked and resting-state fMRI through multi scale imagingR01MH111424 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, CRAIR, MICHAEL C. · 2016 to 2020
$5.2M
Schizophrenia Research FellowshipR25MH071584 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 2005 to 2026
$4.4M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH111424NIMH NIH HHS R25 MH071584NIMH NIH HHS T32 MH019961NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

There is extensive evidence that functional organization of the human brain varies dynamically as the brain switches between task demands, or cognitive states. This functional organization also varies across subjects, even when engaged in similar tasks. To date, the functional network organization of the brain has been considered static. In this work, we use fMRI data obtained across multiple cognitive states (task-evoked and rest conditions) and across multiple subjects, to measure state- and subject-specific functional network parcellation (the assignment of nodes to networks). Our parcellation approach provides a measure of how node-to-network assignment (NNA) changes across states and across subjects. We demonstrate that the brain's functional networks are not spatially fixed, but that many nodes change their network membership as a function of cognitive state. Such reconfigurations are highly robust and reliable to the extent that they can be used to predict cognitive state with up to 97% accuracy. Our findings suggest that if functional networks are to be defined via functional clustering of nodes, then it is essential to consider that such definitions may be fluid and cognitive-state dependent.

Indexed as

ConnectomeAdultBrainHumansMagnetic Resonance ImagingMental ProcessesNerve NetRestConnectivityfMRIFunctionalFunctional parcellationIndividual variabilityTask variability

Identifiers

PMID31574322
PMCPMC7216521
OpenAlexW2975441466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.