Evidence map›Paper›PMID 31574299›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2019

Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms.

Chuck C Blajszczak, Larisa Nonn

Open access · greenAbstract read
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Vitamin D regulation of energy metabolism in cancer.British journal of pharmacology · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chuck C BlajszczakDepartment of Pathology, University of Illinois at Chicago, 840 S Wood St., Chicago, IL 60612, USA.
Larisa NonnDepartment of Pathology, University of Illinois at Chicago, 840 S Wood St., Chicago, IL 60612, USA; University of Illinois Cancer Center, Chicago, IL 60612, USA. Electronic address: lnonn@uic.edu.
University of Illinois Chicago · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Vitamin D Deficiency Leads to Increased Intra‐Prostatic Androgens in African American MenR21CA231610 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NONN, LARISA · 2018 to 2019
$480k
NCATS NIH HHS UL1 TR002003NCI NIH HHS R21 CA231610
6 · The paper itself

Abstract

Vitamin D deficiency has been associated with increased risk for aggressive prostate cancer (PCa). Prostate epithelium has a unique metabolism compared to other tissues. Normal prostate exhibits low levels of mitochondrial respiration and there is a metabolic switch to increased oxidative phosphorylation in PCa. 25-hydroxyvitamin D (25(OH)D) is the major circulating form of vitamin D and is used clinically to determine vitamin D status. Activation of 25(OH)D to the transcriptionally active form, 1,25(OH)

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseCells, CulturedEpithelial CellsGenomicsHumansHydroxylationMaleMitochondriaProstateReceptors, CalcitriolRNA, Small InterferingVitamin DVitamins25-Hydroxyvitamin D3 1-alpha-HydroxylaseCYP27B1 protein, humanReceptors, CalcitriolRNA, Small InterferingVitamin DVitaminsMetabolismProstateVitamin D

Identifiers

PMID31574299
PMCPMC7040883
OpenAlexW2975346270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.