Evidence map›Paper›PMID 31574184›Full record

ArticleStem cells (Dayton, Ohio)2019

Electrical Stimulation of pediatric cardiac-derived c-kit

Joshua T Maxwell, David Trac, Ming Shen, Milton E Brown, Michael E Davis, Myra S Chao, Krittin J Supapannachart, Carly A Zaladonis, Emily Baker, Martin L Li and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Trial offers hope to children with hypoplastic left heart syndrome.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Biomaterials science · 2022
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Joshua T MaxwellDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-7389-5245
David TracWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine, Atlanta, Georgia, USA.
Ming ShenDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Milton E BrownWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine, Atlanta, Georgia, USA.
Michael E DavisDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Myra S ChaoEmory University College of Arts and Sciences, Atlanta, Georgia, USA.
Krittin J SupapannachartEmory University School of Medicine, Atlanta, Georgia, USA.
Carly A ZaladonisEmory University College of Arts and Sciences, Atlanta, Georgia, USA.
Emily BakerEmory University College of Arts and Sciences, Atlanta, Georgia, USA.
Martin L LiEmory University College of Arts and Sciences, Atlanta, Georgia, USA.
Jennifer ZhaoCornell University College of Arts and Sciences, Ithaca, New York, USA.
Daniel I JacobsEmory University College of Arts and Sciences, Atlanta, Georgia, USA.
Emory University · USGeorgia Institute of Technology · USCornell University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
NCATS NIH HHS UL1 TR002378NIGMS NIH HHS T32 GM008169NIH HHS UL1TR002378
6 · The paper itself

Abstract

Nearly 1 in every 120 children born has a congenital heart defect. Although surgical therapy has improved survival, many of these children go on to develop right ventricular heart failure (RVHF). The emergence of cardiovascular regenerative medicine as a potential therapeutic strategy for pediatric HF has provided new avenues for treatment with a focus on repairing or regenerating the diseased myocardium to restore cardiac function. Although primarily tried using adult cells and adult disease models, stem cell therapy is relatively untested in the pediatric population. Here, we investigate the ability of electrical stimulation (ES) to enhance the retention and therapeutic function of pediatric cardiac-derived c-kit

Indexed as

AnimalsCell- and Tissue-Based TherapyCells, CulturedChild, PreschoolDisease Models, AnimalElectric StimulationExtracellular MatrixHeart Defects, CongenitalHeart FailureHumansInfantInfant, NewbornIntegrin beta1MaleMyocytes, CardiacProto-Oncogene Proteins c-kitIntegrin beta1Proto-Oncogene Proteins c-kitCell- and tissue-based therapyElectrical stimulationHeart defects, congenitalHeart failureHumansStem cells

Identifiers

PMID31574184
PMCPMC6916193
OpenAlexW2978645561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.