Evidence map›Paper›PMID 31573933›Full record

ArticleJMIR research protocols2019

Improving Transplant Medication Safety Through a Technology and Pharmacist Intervention (ISTEP): Protocol for a Cluster Randomized Controlled Trial.

Casey L Hall, Cory E Fominaya, Mulugeta Gebregziabher, Sherry K Milfred-LaForest, Kelsey M Rife, David J Taber

Registry-linked trialAbstract read
In one paragraph

Article in JMIR research protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03860818 (Improving Transplant Medication Safety Through a Technology and Pharmacist), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03860818 nacompletednot on this map

Improving Transplant Medication Safety Through a Technology and Pharmacist (ISTEP) Intervention in Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2019 to 2021Enrolled2,196ConditionsTransplantArmsHealth services delivery
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Results of a multicenter cluster-randomized controlled clinical trial testing the effectiveness of a bioinformatics-enabled pharmacist intervention in transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Trial
  2. Trial
  3. Article
  4. Virtual clinical pharmacy services: A model of care to improve medication safety in rural and remote Australian health services.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Casey L HallHealth Equity & Rural Outreach Innovation Center, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, United States.ORCID https://orcid.org/0000-0002-1931-0063
Cory E FominayaDepartment of Pharmacy, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, United States.ORCID https://orcid.org/0000-0002-6265-3774
Mulugeta GebregziabherHealth Equity & Rural Outreach Innovation Center, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, United States.ORCID https://orcid.org/0000-0002-4826-481X
Sherry K Milfred-LaForestDepartment of Pharmacy, VA Northeast Ohio Healthcare System, Cleveland, OH, United States.ORCID https://orcid.org/0000-0003-4076-186X
Kelsey M RifeDepartment of Pharmacy, VA Northeast Ohio Healthcare System, Cleveland, OH, United States.ORCID https://orcid.org/0000-0002-7839-6821
David J TaberHealth Equity & Rural Outreach Innovation Center, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, United States.ORCID https://orcid.org/0000-0001-7273-4589

Funding

Improving Transplant Medication Safety through a TEchnology and Pharmacist (ISTEP) Intervention in VeteransI01HX002130 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI TABER, DAVID J. · 2018 to 2022
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HSRD VA I01 HX002130
6 · The paper itself

Abstract

backgroundMedication errors, adverse drug events, and nonadherence lead to increased health care utilization and increased risk of adverse clinical outcomes, including graft loss, in solid organ transplant recipients. Veterans living with organ transplants represent a population that is at substantial risk for medication safety events and fragmented care coordination issues. To improve medication safety and long-term clinical outcomes in veteran transplant patients, interventions should address interorganizational system failures and provider-level and patient-level factors.

objectiveThis study aims to measure the clinical and economic effectiveness of a pharmacist-led, technology-enabled intervention, compared with usual care, in veteran organ transplant recipients.

methodsThis is a 24-month prospective, parallel-arm, cluster-randomized, controlled multicenter study. The pharmacist-led intervention uses an innovative dashboard system to improve medication safety and health outcomes, compared with usual posttransplant care. Pharmacists at 10 study sites will be consented into this study before undergoing randomization, and 5 sites will then be randomized to each study arm. Approximately, 1600 veteran transplant patients will be included in the assessment of the primary outcome across the 10 sites.

resultsThis study is ongoing. Institutional review board approval was received in October 2018 and the study opened in March 2019. To date there are no findings from this study, as the delivery of the intervention is scheduled to occur over a 24-month period. The first results are expected to be submitted for publication in August 2021.

conclusionsWith this report, we describe the study design, methods, and outcome measures that will be used in this ongoing clinical trial. Successful completion of the Improving Transplant Medication Safety through a Technology and Pharmacist Intervention study will provide empirical evidence of the effectiveness of a feasible and scalable technology-enabled intervention on improving medication safety and costs. CLINICAL TRIAL: ClinicalTrials.gov NCT03860818; https://clinicaltrials.gov/ct2/show/NCT03860818. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/13821.

Indexed as

adherencemedication adherencemedication errorstransplant

Identifiers

PMID31573933
PMCPMC6774238

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.