Evidence map›Paper›PMID 31573837›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

No association between cortical lesions and leptomeningeal enhancement on 7-Tesla MRI in multiple sclerosis.

Mehrnaz Ighani, Samuel Jonas, Izlem Izbudak, Seongjin Choi, Alfonso Lema-Dopico, Jun Hua, Erin E O'Connor, Daniel M Harrison

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Decoding Gray Matter Involvement in Multiple Sclerosis via Imaging.Neuroimaging clinics of North America · 2024
    Review
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  10. Review
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  12. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mehrnaz IghaniUniversity of Maryland, College Park, MD, USA.
Samuel JonasDepartment of Radiology, University of Maryland Medical Center, Baltimore, MD, USA.
Izlem IzbudakDepartment of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Seongjin ChoiDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Alfonso Lema-DopicoDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jun HuaDepartment of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA/Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA/F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Erin E O'ConnorDepartment of Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Daniel M HarrisonDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA/ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8707-2004
University of Maryland, Baltimore · USJohns Hopkins University · USUniversity of Maryland, College Park · US

Funding

Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and CognitionR01AG034852 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 2010 to 2020
$9.2M
In vivo assessment of meningeal inflammation and its clinical impact in multiple sclerosis by 7 Tesla MRIR01NS104403 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, DANIEL M · 2018 to 2022
$3.1M
Grey Matter of Lesions and Neurodegeration in Multiple Sclerosis on 7-Telsa MRIK23NS072366 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, DANIEL M · 2013 to 2017
$928k
NIA NIH HHS R01 AG034852NINDS NIH HHS K23 NS072366NINDS NIH HHS L30 NS088825NINDS NIH HHS R01 NS104403
6 · The paper itself

Abstract

backgroundAutopsy data suggest a causative link between meningeal inflammation and cortical lesions (CLs) in multiple sclerosis (MS).

objectiveTo use leptomeningeal enhancement (LME) and CLs on 7-Tesla (7T) magnetic resonance imaging (MRI) to investigate associations between meningeal inflammation and cortical pathology.

methodsForty-one participants with MS underwent 7T MRI of the brain. CLs and foci of LME were quantified.

resultsAll MS participants had CLs; 27 (65.8%) had >1 focus of LME. Except for hippocampal CL count (ρ = 0.32 with spread/fill-sulcal pattern LME,

conclusionThis study supports a relationship between LME and cortical GM atrophy but does not support an association of LME and neocortical CLs. This may indicate that meningeal inflammation is involved with neurodegenerative inflammatory processes, rather than focal lesion development.

Indexed as

AdultBrainFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMeningesMiddle AgedMultiple SclerosisNeuroimaging7 Tesla7T MRIcortical lesionshippocampal lesionsLeptomeningeal enhancementmeningeal inflammationmultiple sclerosis

Identifiers

PMID31573837
PMCPMC7021560
OpenAlexW2977847630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.