Evidence map›Paper›PMID 31573793›Full record

ArticleACS chemical biology2019

Transcriptional Bypass of DNA-Protein and DNA-Peptide Conjugates by T7 RNA Polymerase.

Shaofei Ji, Jenna Thomforde, Colette Rogers, Iwen Fu, Suse Broyde, Natalia Y Tretyakova

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Targeting DNA-Protein CrosslinksFrontiers in molecular biosciences · 2022
    Review
  13. Review
  14. Comparative Nucleosomal Reactivity of 5-Formyl-Uridine and 5-Formyl-Cytidine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. DNA-Histone Cross-Links: Formation and Repair.Frontiers in cell and developmental biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jenna Thomforde
Colette Rogers
Iwen FuDepartment of Biology New York University , New York , New York 10003 , United States.
Suse BroydeDepartment of Biology New York University , New York , New York 10003 , United States.ORCID 0000-0002-3802-7511
Natalia Y TretyakovaORCID 0000-0002-0621-6860
University of Minnesota · USNew York University · US

Funding

DNA Protein Cross-Links:Cellular Effects and Repair MechanismsR01ES023350 · NIEHS · UNIVERSITY OF MINNESOTA · PI CAMPBELL, COLIN R, TRETYAKOVA, NATALIA Y · 2014 to 2023
$5.0M
DNA Lesion Structures: Mutagenicity and RepairR01CA075449 · NCI · NEW YORK UNIVERSITY · PI BROYDE, SUSE · 1997 to 2015
$4.3M
Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase BypassR01ES025987 · NIEHS · NEW YORK UNIVERSITY · PI BROYDE, SUSE · 2016 to 2025
$3.6M
NCI NIH HHS R01 CA075449NIEHS NIH HHS R01 ES023350NIEHS NIH HHS R01 ES025987
6 · The paper itself

Abstract

DNA-protein cross-links (DPCs) are unusually bulky DNA adducts that block the access of proteins to DNA and interfere with gene expression, replication, and repair. We previously described DPC formation at the N7-guanine position of DNA in human cells treated with antitumor nitrogen mustards and platinum compounds and have shown that DPCs can form endogenously at DNA epigenetic mark 5-formyl-dC. However, insufficient information is available about the effects of these structurally distinct DPCs on transcription. In the present work, we employ a combination of

Indexed as

Transcription, GeneticDNADNA-Directed RNA PolymerasesPeptidesProteinsViral Proteinsbacteriophage T7 RNA polymeraseDNADNA-Directed RNA PolymerasesPeptidesProteinsViral Proteins

Identifiers

PMID31573793
PMCPMC8177100
OpenAlexW2978199079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.