ArticleIET nanobiotechnology2019
Reduced graphene oxide: osteogenic potential for bone tissue engineering.
Article in IET nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent Advances in Periodontal Regenerative Medicine: A Focus on the Role of Mechanical Stimulation.Biomedicines · 2025Review
- Modulating cell adhesion and infiltration in advanced scaffold designs based on PLLA fibers with rGO and MXene (TiMaterials today. Bio · 2025Article
- Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration.Biology · 2024Review
- Graphene in 3D Bioprinting.Journal of functional biomaterials · 2024Review
- Graphene: A Multifaceted Carbon-Based Material for Bone Tissue Engineering Applications.ACS omega · 2024Review
- Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application.Biomaterials research · 2023Article
- Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach.Journal of nanobiotechnology · 2023Review
- Aerogel-Based Materials in Bone and Cartilage Tissue Engineering-A Review with Future Implications.Gels (Basel, Switzerland) · 2023Review
- Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties.International journal of biomaterials · 2023Review
- In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review.Pharmaceutics · 2022Review
- Fighting Antibiotic-Resistant Bacterial Infections by Surface Biofunctionalization of 3D-Printed Porous Titanium Implants with Reduced Graphene Oxide and Silver Nanoparticles.International journal of molecular sciences · 2022Article
- Fabrication and characterization of PHEMA-gelatin scaffold enriched with graphene oxide for bone tissue engineering.Journal of orthopaedic surgery and research · 2022Article
- Development of Graphene-Based Materials in Bone Tissue Engineaering.Global challenges (Hoboken, NJ) · 2022Review
- Graphene-Based Nanomaterials for Dental Applications: Principles, Current Advances, and Future Outlook.Frontiers in bioengineering and biotechnology · 2022Review
- Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering.Nano-micro letters · 2021Article
- Gelatin reduced Graphene Oxide Nanosheets as Kartogenin Nanocarrier Induces Rat ADSCs Chondrogenic Differentiation Combining with Autophagy Modification.Materials (Basel, Switzerland) · 2021Article
- Engineering Functional Graphenic Materials for Bone Repair.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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5 authors.
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Abstract
Collagen (Col) type I, as the major component of the bone extracellular matrix has been broadly studied for bone tissue engineering. However,inferior mechanical properties limit its usage for load bearing applications. In this research, freeze dried Col scaffolds are coated with graphene oxide (GO) through a covalent bond of the amine Col with the graphene carboxyl groups. The prepared scaffolds were then reduced using a chemical agent. Scanning electron microscopy exhibited a porous structure for the synthesized scaffolds with an approximate pore size of 100-220 ± 12 µm, which is in the suitable range for bone tissue engineering application. Reducing the GO coating improved the compressive modulus of the Col from 250 to 970 kPa. Apatite formation was also indicated by immersing the scaffolds in simulated body fluid after five days. The cytocompatibility of the scaffolds, using human bone marrow-derived mesenchymal stem cells, was confirmed with MTT analysis. Alkaline phosphatase assay revealed that reducing the Col-GO scaffolds can effectively activate the differentiation of hBM-MSCs into osteoblasts after 14 days, even without the addition of an osteogenic differentiation medium. The results of this study highlight that GO and its reduced form have considerable potential as bone substitutes for orthopaedic and dental applications.
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