ArticleIET nanobiotechnology2019
Multi-threshold and multi-input DNA logic design style for profiling the microRNA biomarkers of real cancers.
Article in IET nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Fluorescence-Based Multimodal DNA Logic Gates.Nanomaterials (Basel, Switzerland) · 2024Article
- PhotocleavableChemical reviews · 2023Review
- Advances in Applications of Molecular Logic Gates.ACS omega · 2021Review
- Analytical design of multi-threshold and high fan-in DNA-based logical sensors to profile the pattern of MS microRNAs.Biomedical engineering letters · 2021Article
- RNA secondary structured logic gates for profiling the microRNA cancer biomarkers.IET nanobiotechnology · 2020Article
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2 authors.
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Abstract
Early detection of cancer is very critical because it can reduce the treatment risk and cost. MicroRNAs (miRNAs) have been introduced in recent years as an efficient class of biomarkers for cancer early detection. Now, real-time polymerase chain reaction has been used to profile the miRNA expression, which is costly, time consuming and low accuracy. Most recently, DNA logic gates are used to detect the miRNA expression level that is more accurate and faster than previous methods. The DNA-based logic gates face with serious challenges such as the large complexity and low scalability. In this study, the authors proposed a methodology to design multi-threshold and multi-input DNA-based logic gates in response to specific miRNA inputs in live mammalian cells. The proposed design style can simultaneously recognise multiple miRNAs with different rising and falling thresholds. The design style has been evaluated on the lung cancer biomarkers and the experimental results show the efficiency of the proposed method in terms of accuracy, efficiency and speed.
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