Evidence map›Paper›PMID 31573404›Full record

ArticleRadiology2019

Three-dimensional US Fractional Moving Blood Volume: Validation of Renal Perfusion Quantification.

Alec W Welsh, J Brian Fowlkes, Stephen Z Pinter, Kimberly A Ives, Gabe E Owens, Jonathan M Rubin, Oliver D Kripfgans, Pádraig Looney, Sally L Collins, Gordon N Stevenson

Registry-linked trialAbstract read
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05326191 (First-trimester Placental Ultrasound Study), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05326191 completednot on this mapstarted 2022, after this paper: background citation

First-trimester Placental Ultrasound Study (First PLUS): an Observational Cohort Study to Assess the Clinical Utility of the OxNNet Toolkit for the Prediction of Adverse Pregnancy Outcomes.

TypeobservationalSponsorPerspectumRan2022 to 2023Enrolled4,000ConditionsFetal Growth Complications, Pregnancy ComplicationsArmsUltrasound
3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Reference charts for first-trimester placental three-dimensional fractional moving blood volume derived using OxNNet.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
  7. Article
  8. Article
  9. Automated multivolume placental reconstruction using three-dimensional power Doppler ultrasound and infrared camera tracking.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Umbilical Vein Pulse Wave Spectral Analysis: A Possible Method for Placental Assessment Through Evaluation of Maternal and Fetal Flow Components.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Fully Automated 3-D Ultrasound Segmentation of the Placenta, Amniotic Fluid, and Fetus for Early Pregnancy Assessment.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alec W WelshFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).
J Brian FowlkesFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).ORCID 0000-0002-4536-3919
Stephen Z PinterFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).
Kimberly A IvesFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).ORCID 0000-0001-8444-1927
Gabe E OwensFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).
Jonathan M RubinFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).ORCID 0000-0002-6643-486X
Oliver D KripfgansFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).ORCID 0000-0003-2905-1496
Pádraig LooneyFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).
Sally L CollinsFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).
Gordon N StevensonFrom the School of Women's and Children's Health, Faculty of Medicine (A.W.W., G.N.S.), and Department of Maternal-Fetal Medicine (A.W.W.), University of New South Wales, Royal Hospital for Women, Locked Bag 2000, Barker Street, Randwick, NSW 2031, Australia; Departments of Radiology (J.B.F., S.Z.P., J.M.R., O.D.K.), Biomedical Engineering (K.A.I.), and Pediatrics (G.E.O.), University of Michigan Health System, Ann Arbor, Mich; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, England (P.L., S.L.C.); and Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, England (S.L.C.).ORCID 0000-0002-2809-8084

Funding

Development of real-time, automated 3D ultrasound tools for the study of placental invasion and morphologyU01HD087209 · NICHD · HACKENSACK UNIVERSITY MEDICAL CENTER · PI COLLINS, SALLY LOUISE, ZAMUDIO, STACY · 2015 to 2015
$3.3M
NICHD NIH HHS U01 HD087209
6 · The paper itself

Abstract

Background Three-dimensional (3D) fractional moving blood volume (FMBV) derived from 3D power Doppler US has been proposed for noninvasive approximation of perfusion. However, 3D FMBV has never been applied in animals against a ground truth. Purpose To determine the correlation between 3D FMBV and the reference standard of fluorescent microspheres (FMS) for measurement of renal perfusion in a porcine model. Materials and Methods From February 2017 to September 2017, adult pigs were administered FMS before and after measurement of renal 3D FMBV at baseline (100%) and approximately 75%, 50%, and 25% flow levels by using US machines from two different vendors. The 3D power Doppler US volumes were converted and segmented, and correlations between FMS and 3D FMBV were made with simple linear regression (

Indexed as

AnimalsBlood Flow VelocityBlood VolumeFluorescenceImaging, Three-DimensionalKidneyMicrospheresModels, AnimalReproducibility of ResultsSwineUltrasonography, Doppler

Identifiers

PMID31573404
PMCPMC6800606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.