ArticleTurkish journal of anaesthesiology and reanimation2019
Clinical Analysis of Propofol, Etomidate and an Admixture of Etomidate and Propofol for Induction of General Anaesthesia.
Article in Turkish journal of anaesthesiology and reanimation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of different doses of alfentanil on cardiovascular response to rapid sequence intubation in elderly patients: a parallel-controlled randomized trial.BMC anesthesiology · 2024Trial
- Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial.International journal of clinical pharmacy · 2023Trial
- Unconscious classification of quantitative electroencephalogram features from propofol versus propofol combined with etomidate anesthesia using one-dimensional convolutional neural network.Frontiers in medicine · 2024Article
- Prevalence and risk factors of post-operative nausea and vomiting in a tertiary-care hospital: A cross-sectional observational study.Medical journal, Armed Forces India · 2022Article
- Discovery of the EL-0052 as a potential anesthetic drug.Computational and structural biotechnology journal · 2021Article
- Comparative efficacy of high-flow nasal cannula versus conventional oxygen delivery during procedural sedation for ovum pickup in assisted reproductive technology.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the clinical outcome following induction of general anaesthesia with intravenous (IV) injection of propofol (P), etomidate (E) or a 50% admixture of propofol and etomidate (PE).
methodsIn this prospective, randomised, double-blind controlled study, patients 18-60 years of age who were undergoing elective surgery with general anaesthesia were randomised to receive either propofol 2.5 mg kg
resultsWe observed a decrease in systemic haemodynamics from baseline following induction in group P compared to groups E and PE (p<0.05). Incidence of myoclonus was reduced from 76.6% in group E to 6.6% in group PE (p<0.001). There was also a reduction in reported pain upon injection in group PE compared to group P (p<0.001). Although we found no statistically significant difference between the three groups when assessing postoperative nausea and vomiting, these symptoms were more prevalent in groups E and PE than in group P.
conclusionUsing an admixture of etomidate and propofol as the induction agent reduced the incidence of side effects observed with use of either drug alone such as pain upon injection, myoclonus and haemodynamic instability.
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Registered trials
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