ArticleCurrent opinion in systems biology2019
Recombination drives the evolution of mutational robustness.
Article in Current opinion in systems biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Evolutionary Simulations Reveal Role for Genomic Recombination in the Evolution of Gene Regulatory Network Complexity and Robustness.Genome biology and evolution · 2026Article
- Causes and consequences of a complex recombinational landscape in the antGenome research · 2024Article
- Experimental Evolution Studies in Φ6 Cystovirus.Viruses · 2024Review
- Co-transfer of functionally interdependent genes contributes to genome mosaicism in lambdoid phages.Microbial genomics · 2022Article
- Conflicting effects of recombination on the evolvability and robustness in neutrally evolving populations.PLoS computational biology · 2022Review
- Sex-specific effects of inbreeding on body colouration and physiological colour change in the cichlid fish Pelvicachromis taeniatus.BMC ecology and evolution · 2022Article
- Recombination and mutational robustness in neutral fitness landscapes.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recombination can impose fitness costs as beneficial parental combinations of alleles are broken apart, a phenomenon known as recombination load. Computational models suggest that populations may evolve a reduced recombination load by reducing either the likelihood of recombination events (bring interacting loci in physical proximity) or the strength of interactions between loci (make loci more independent of one another). We review evidence for each of these possibilities and their consequences for the genotype-fitness relationship. In particular, we expect that reducing interaction strengths between loci will lead to genomes that are also robust to mutational perturbations, but reducing recombination rates alone will not. We note that both mechanisms most likely played a role in the evolution of extant populations, and that both can result in the frequently-observed pattern of physical linkage between interacting loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.