Evidence map›Paper›PMID 31572681›Full record

ArticleFrontiers in oncology2019

The Highly Pure Neem Leaf Extract, SCNE, Inhibits Tumorigenesis in Oral Squamous Cell Carcinoma via Disruption of Pro-tumor Inflammatory Cytokines and Cell Signaling.

Jay Morris, Cara B Gonzales, Jorge J De La Chapa, April B Cabang, Christos Fountzilas, Mandakini Patel, Stephanie Orozco, Michael J Wargovich

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Exploring the therapeutic potential of Neem (Annals of translational medicine · 2022
    Review
  9. Review
  10. Review
  11. Exploring the role of3 Biotech · 2021
    Review
  12. Administration of neem (Journal of advanced veterinary and animal research · 2020
    Article
  13. Review
  14. Review
  15. Identification of an Immune Score-Based Gene Panel with Prognostic Power for Oral Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  16. Evaluation of the Effect of an Aqueous Extract ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jay MorrisDepartment of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
Cara B GonzalesDepartment of Comprehensive Dentistry, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
Jorge J De La ChapaDepartment of Comprehensive Dentistry, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
April B CabangDepartment of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
Christos FountzilasDepartment of Medicine, GI Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Mandakini PatelDepartment of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
Stephanie OrozcoDepartment of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
Michael J WargovichDepartment of Molecular Medicine, Long School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · USRoswell Park Comprehensive Cancer Center · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a deadly disease that comprises 60% of all head and neck squamous cell cancers. The leaves of the Neem tree (

Indexed as

Azadirachta indicaneemoral canceroral squamous cell carcinomaprevention

Identifiers

PMID31572681
PMCPMC6753233
OpenAlexW2970034723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.