Evidence map›Paper›PMID 31572668›Full record

ArticleWorld journal of orthopedics2019

Single- and double-dose of platelet-rich plasma

Mehdi Tavassoli, Nasser Janmohammadi, Akram Hosseini, Soraya Khafri, Seyed Mokhtar Esmaeilnejad-Ganji

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of orthopedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06543368 (Low-Cost Platelet-Rich Plasma Injection for the Management of Hemarthropathy), which is not on this map. Cited by 33 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06543368 nacompletednot on this mapstarted 2024, after this paper: background citation

Low-Cost Platelet-Rich Plasma Injection for the Management of Hemarthropathy

TypeinterventionalSponsorUniversity of UtahRan2024 to 2025Enrolled14ConditionsHemarthrosis, HemophiliaArmsIntra articular PRP Injection
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehdi TavassoliStudent Research Committee, School of Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran.
Nasser JanmohammadiDepartment of Orthopedics, Babol University of Medical Sciences, Babol 47176-47745, Iran.
Akram HosseiniDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran.
Soraya KhafriBiostatistics and Epidemiology Department, Medicine Faculty, Babol University of Medical Sciences, Babol 47176-47745, Iran.
Seyed Mokhtar Esmaeilnejad-GanjiClinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol 47176-47745, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatelet-rich plasma (PRP) and hyaluronic acid have been shown to be useful in the treatment of knee osteoarthritis. However, investigations comparing the efficacy of these two drugs together are insufficient.

aimTo compare the outcomes of PRP

methodsThis randomized controlled trial study involved 95 patients. Thirty-one subjects received a single injection of PRP (group PRP-1), 33 subjects received two injections of PRP at an interval of 3 wk (group PRP-2) and 31 subjects received three injections of hyaluronic acid at 1-wk intervals (group hyaluronic acid). The patients were investigated prospectively at the enrollment and at 4-, 8- and 12-wk follow-up with the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Visual Analogue Scale questionnaires.

resultsPercentages of patients experiencing at least a 30% decrease in the total score for the WOMAC pain subscale from baseline to wk 12 of the intervention were 86%, 100% and 0% in the groups PRP-1, PRP-2 and hyaluronic acid, respectively (

conclusionPRP is a safe and efficient therapeutic option for treatment of knee osteoarthritis. It was demonstrated to be significantly better than hyaluronic acid. We also found that the efficacy of PRP increases after multiple injections.

Indexed as

Hyaluronic acidKneeOsteoarthritisPainPlatelet-rich plasma

Identifiers

PMID31572668
PMCPMC6766465

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.