Evidence map›Paper›PMID 31572607›Full record

ArticleArchives of public health = Archives belges de sante publique2019

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017.

Elena Viktorovna Bochkareva, Ekaterina Kronidovna Butina, Irina Vitalievna Kim, Anna Vasilievna Kontsevaya, Oxana Mikhailovna Drapkina, David Leon, Martin McKee

Abstract readScoping Review
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elena Viktorovna BochkarevaLaboratory of Drug Prevention in Primary Healthcare, Federal State Institution "National Medical Research Center for Preventive Medicine", Petroverigsky per., building 10/3, Moscow, 101990 Russia.
Ekaterina Kronidovna ButinaLaboratory of Drug Prevention in Primary Healthcare, Federal State Institution "National Medical Research Center for Preventive Medicine", Petroverigsky per., building 10/3, Moscow, 101990 Russia.
Irina Vitalievna KimLaboratory of Drug Prevention in Primary Healthcare, Federal State Institution "National Medical Research Center for Preventive Medicine", Petroverigsky per., building 10/3, Moscow, 101990 Russia.ORCID 0000-0001-5122-4723
Anna Vasilievna KontsevayaLaboratory of Drug Prevention in Primary Healthcare, Federal State Institution "National Medical Research Center for Preventive Medicine", Petroverigsky per., building 10/3, Moscow, 101990 Russia.
Oxana Mikhailovna DrapkinaLaboratory of Drug Prevention in Primary Healthcare, Federal State Institution "National Medical Research Center for Preventive Medicine", Petroverigsky per., building 10/3, Moscow, 101990 Russia.
David Leon2London School of Hygiene and Tropical Medicine, London, UK.
Martin McKee2London School of Hygiene and Tropical Medicine, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundArterial hypertension (HT) is common in the Russian adult population, with half of affected individuals inadequately controlled. Low adherence to medication seems likely to be a factor. We report a scoping review of studies on adherence to antihypertensive therapy (AHT) in Russia to determine the extent of research undertaken, the frequency of adherence among adults diagnosed with HT, methodologies used in the studies, and their ability to describe determinants of adherence.

methodsA scoping review of published studies that have assessed adherence to AHT in Russian HT patients searched the main Russian and international electronic databases eLIBRARY.ru, Russian Medicine, Embase, MEDLINE for full-text reports published in the Russian language between 2000 and 2017. The last search was on November 28, 2017. Among 520 reports identified, 31 were included in the review.

resultsEighteen studies assessed adherence using the 4-item Morisky Medication Adherence Scale (MMAS-4); others used bespoke questionnaires or pill counts. 25 studies assessed levels of adherence, 11 examined its determinants, and 18 examined intervention strategies. The proportion of "adherent" patients varied from 11 to 44% using the MMAS-4, from 23 to 74% when using bespoke questionnaires, and from 5 to 43% when using pill counts. Adherence was associated with sociodemographic factors, access to free drugs provided through the Medicine Assistance Scheme (MAS), use of home blood pressure (BP) monitoring, anxiety, and comorbidity. There was no evidence that adherence was associated with income or physical activity. Evidence of an association between MAS, grade of HT, or experience of hypertensive crisis was inconclusive. Various methods to improve adherence were studied including patient education (improved from 1.8 to 3.9 points,

conclusionsThe main determinants of adherence to AHT are sociodemographic characteristics, the severity of HT, and presence of comorbidity. Patient education and use of fixed-dose combinations of drugs were identified as most important for improving adherence. Most studies assessing adherence use self-reported methods so there is a need for greater use of objective methods.

trial registrationThis scoping review has not been registered.

Indexed as

HypertensionMedication adherenceScoping review

Identifiers

PMID31572607
PMCPMC6760051

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.