ArticleArchives of medical science : AMS2019
Expression of adiponectin receptors 1 and 2 and the leptin receptor in human adrenal tumors.
Article in Archives of medical science : AMS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- The level of accordance between preoperative and postoperative diagnosis in patients undergoing adrenalectomy - a study of 230 consecutive cases.Archives of medical science : AMS · 2024Article
- Review of Diagnostic Modalities for Adrenal Incidentaloma.Journal of clinical medicine · 2023Review
- Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis.Frontiers in endocrinology · 2023Article
- The role of selected adipokines in tumorigenesis and metabolic disorders in patients with adrenal tumors.Archives of medical science : AMS · 2023Article
- Overexpression of Adiponectin Receptors in Opium Users with and without Cancer.Clinical pharmacology : advances and applications · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe role of adipokines in neoplasms not related to obesity is unclear. The presence of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) as well as the leptin receptor (Ob-R) has been recognized in human adrenal tumors. The authors of the present study were the first to compare the expression of these receptors in histopathologically distinct adrenal tumors. MATERIAL AND
methodsThe study encompassed tissue specimens of 128 patients with adrenal tumors (28 adrenal cortical adenomas (CA), 35 cortical nodular hyperplasia tumors (CNH), 20 cortical carcinomas (CC), 40 pheochromocytomas (PHEO), 5 malignant pheochromocytomas (PHEOM)) operated on at a single clinical center. The expression of the adiponectin receptors AdipoR1 and AdipoR2 as well as the leptin receptor Ob-R was assessed by immunohistochemistry. The results were correlated with body mass index (BMI) and gender of the patients.
resultsAdipoR1 expression was significantly higher in cortical cancers (
conclusionsThese novel findings suggest that adiponectin and leptin receptors could play a regulatory role in human adrenal neoplasms.
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