Evidence map›Paper›PMID 31572470›Full record

ArticleArchives of medical science : AMS2019

Expression of miRNAs-122, -192 and -499 in end stage renal disease associated with acute myocardial infarction.

Lobna Abdelsalam, Alshaymaa A Ibrahim, Aliaa Shalaby, Noha Osman, Assem Hashad, Dina Badawy, Hany Elghobary, Eman Amer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. lncRNA SNHG6 improves placental villous cell function in anArchives of medical science : AMS · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lobna AbdelsalamClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Alshaymaa A IbrahimClinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Aliaa ShalabyClinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Noha OsmanNephrology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Assem HashadCardiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dina BadawyClinical and Chemical Pathology department, Alzahraa University hospital, Al-azhar University, Cairo, Egypt.
Hany ElghobaryClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Eman AmerBiochemistry Department, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt.
Cairo University · EGNational Research Centre · EGAhram Canadian University · EGAl-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNew diagnostic tools are needed to accurately detect acute myocardial infarction (AMI) in patients with end stage renal disease (ESRD) presenting with ischemic chest pain. We aimed in this study to investigate circulating miR-122, -192 and -499 expression levels in patients with AMI on top of ESRD and evaluate the potential of these miRNAs as blood-based biomarkers for AMI in patients with ESRD. MATERIAL AND

methodsThe study included 80 ESRD patients without AMI, 80 patients with ESRD associated with AMI and 60 healthy subjects. Assessment of microRNAs was done using SYBR Green based real-time PCR.

resultsLevels of miR-122 were 28-fold and 20-fold higher in controls than in ESRD patients with or without AMI respectively (

conclusionsAltered expression of miR-122 and -192 may contribute in pathogenesis of ESRD. MiR-192 and -499 may serve as potential biomarkers for AMI in ESRD. Further studies are needed to correlate these miRNAs with disease progression and outcome.

Indexed as

acute myocardial infarctionchronic kidney diseaseend stage renal diseasemiRNA

Identifiers

PMID31572470
PMCPMC6764293
OpenAlexW2969298674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.