ArticleArchives of medical science : AMS2019
Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents.
Article in Archives of medical science : AMS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The effects of macro-algae supplementation on serum lipid, glycaemic control and anthropometric indices: A systematic review and meta-analysis of clinical trials.Endocrinology, diabetes & metabolism · 2023Pooled it
- The link between nutrient intake and anthropometric indices with COVID-19 infection in pregnant women.BMC pregnancy and childbirth · 2026Article
- Association of Type 2 Diabetes Mellitus With Dietary Vitamin B12 Intake in Individuals With Different Fat Mass and Obesity-Associated (FTO) Genotypes.Food science & nutrition · 2026Article
- Critical roles of m6A demethylase FTO in ovarian aging.Biogerontology · 2026Review
- FTO in cardiovascular diseases: mechanisms, context dependence, and translational opportunities.Frontiers in cell and developmental biology · 2026Review
- Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.Molecular biology reports · 2025Article
- Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes.Clinical and experimental medicine · 2024Article
- Review
- Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people.Archives of medical science : AMS · 2023Article
- The effect of FTO rs9939609 polymorphism on the association between colorectal cancer and dietary fiber.Frontiers in nutrition · 2022Article
- C-myc/TSPEAR-AS2 Axis Facilitates Breast Cancer Growth and Metastasis in a GLUT1-Dependent Glycolysis Manner.BioMed research international · 2022Article
- Sevoflurane Inhibits lncRNA HOTAIR-Modulated Stability of HK2 mRNA in a m6A-Dependent Manner to Dampen Aerobic Glycolysis and Proliferation in Lung Cancer.BioMed research international · 2022Article
- Intake of food groups and cervical cancer in women at risk for cervical cancer: A nested case-control study.Caspian journal of internal medicine · 2022Article
- The correlation between serum inflammatory, antioxidant, glucose handling biomarkers, and Dietary Antioxidant Index (DAI) and the role of DAI in obesity/overweight causation: population-based case-control study.International journal of obesity (2005) · 2021Article
- The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases.Genes & diseases · 2021Review
- Article
- The association between fat mass and obesity-associated (FTO) genotype and serum vitamin D level in breast cancer patients.Journal of cellular and molecular medicine · 2021Article
- The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.Molecular genetics & genomic medicine · 2021Article
- The Association of Fat-Mass-and Obesity-Associated Gene Polymorphism (rs9939609) With Colorectal Cancer: A Case-Control Study.Frontiers in oncology · 2021Article
- Relationship between the skeletal muscle mass index and physical activity of Japanese children: A cross-sectional, observational study.PloS one · 2021Observational
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe modifying effect of FTO gene expression level on change in body mass index and body composition has not been studied before. This study aimed to investigate the association between change in the expression level of the FTO gene and changes in anthropometric measurements in obese and overweight adolescent boys. MATERIAL AND
methodsEighty-four boys aged 12 to 16 years participated in this longitudinal study. A Bio Impedance Analyzer (BIA) was used to estimate percentage of body fat (%BF) and percentage of skeletal muscle (%SM). The FTO gene expression level in peripheral blood mononuclear cells was assessed using quantitative real-time PCR (qPCR). All measurements were performed at baseline and after 18 weeks.
resultsAfter 18 weeks, mean weight was reduced by 2.39 kg, body mass index by 0.09 kg/m
conclusionsFTO gene expression change was associated with change in %SM in male adolescents. Future studies are required to assess the interactions between FTO gene expression in different tissues and body composition.
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