Evidence map›Paper›PMID 31572424›Full record

ArticleDementia and geriatric cognitive disorders extra

Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment.

Naira Goukasian, Shai Porat, Anna Blanken, David Avila, Dimitar Zlatev, Sona Hurtz, Kristy S Hwang, Jonathan Pierce, Shantanu H Joshi, Ellen Woo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Predicting Future Brain Atrophy Based on Longitudinal MRI.medRxiv : the preprint server for health sciences · 2025
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  15. Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Naira GoukasianUniversity of Vermont, Larner College of Medicine, Burlington, Vermont, USA.
Shai PoratDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Anna BlankenDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
David AvilaIrvine School of Medicine, University of California, Irvine, California, USA.
Dimitar ZlatevMassachusetts General Hospital, Boston, Massachusetts, USA.
Sona HurtzDrexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Kristy S HwangEmory University School of Medicine, Atlanta, Georgia, USA.
Jonathan PierceDepartment of Neurology, University of California, Los Angeles, California, USA.
Shantanu H JoshiDepartment of Neurology, University of California, Los Angeles, California, USA.
Ellen WooDepartment of Neurology, University of California, Los Angeles, California, USA.
Liana G ApostolovaDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
NIA NIH HHS P30 AG010133
6 · The paper itself

Abstract

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors.

Indexed as

Alzheimer's diseaseHippocampal atrophyImagingMild cognitive impairmentMRIVentricular enlargement

Identifiers

PMID31572424
PMCPMC6751474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.