ReviewFrontiers in immunology2019
Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome.
Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Prevalence of type 2 diabetes among global Indigenous adult populations: a systematic review.Diabetologia · 2026Pooled it
- Trends and inequalities in acute respiratory tract infections in Indonesia: an application of the World Health Organization's Health Equity Assessment Toolkit.Tropical medicine and health · 2026Article
- Global burden and trend of ischemic heart disease and its attributable risk factors among women of childbearing age from 1990 to 2021.Frontiers in cardiovascular medicine · 2026Article
- Global Mortality and Disability-Adjusted Life Years Attributable to Tobacco Exposure Among Middle-Aged and Older Adults With Type 2 Diabetes, 1990-2021: A Systematic Analysis of GBD 2021 Data With Projections to 2042.Journal of diabetes research · 2026Article
- The declining but persistent burden of lower respiratory infections from secondhand smoke in children aged under 14 years: Global trends 1990-2021 and forecasts to 2035, based on a secondary dataset analysis of Global Burden of Disease (GBD) 2021.Tobacco induced diseases · 2026Article
- Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization.Nature communications · 2025Article
- Population genomics of Aedes albopictus across remote Pacific islands for genetic biocontrol considerations.PLoS neglected tropical diseases · 2025Article
- Chemical Characterization of Alphitonia neocaledonica (Schltr.) Guillaumin Bark Extract and Its Anti-Inflammatory Activities.Chemistry & biodiversity · 2025Article
- Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes.Current neurology and neuroscience reports · 2025Review
- Palau: Non-Communicable Disease Off-Island Treatment Referrals 2020-2022.International journal of environmental research and public health · 2025Article
- Gut Microbiota of Sarawak's "Orang Ulu" Indigenous Community in East Malaysia Reveals Vanish Microbes: A Comparison With Urban Communities.British journal of biomedical science · 2025Article
- Global burden and trend of stroke attributable to metabolic risks among young adults (20-39 years old) from 1990 to 2021.Frontiers in cardiovascular medicine · 2025Article
- A Quantitative Analysis of Human and Material Resources for Endoscopy Services in Pacific Island Countries.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Temporal trends in cross-country inequalities of stroke and subtypes burden from 1990 to 2021: a secondary analysis of the global burden of disease study 2021.EClinicalMedicine · 2024Article
- Native Hawaiian and Pacific Islander populations in genomic research.NPJ genomic medicine · 2024Review
- Levels and functionality of Pacific Islanders' hybrid humoral immune response to BNT162b2 vaccination and delta/omicron infection: A cohort study in New Caledonia.PLoS medicine · 2024Article
- High seropositivity against NDO-LID in a group of household contacts of leprosy patients. Are we close to leprosy elimination in Colombia?Pathogens and global health · 2023Observational
- Indigenous communities and influenza: protocol for a systematic review and meta-analysis.Systematic reviews · 2023Article
- Global, Regional, and National Advances Toward the Management of Rheumatic Heart Disease Based on the Global Burden of Disease Study 2019.Journal of the American Heart Association · 2023Article
- The Gut Microbiome of an Indigenous Agropastoralist Population in a Remote Area of Colombia with High Rates of Gastrointestinal Infections and Dysbiosis.Microorganisms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Pacific region, also referred to as Oceania, is a geographically widespread region populated by people of diverse cultures and ethnicities. Indigenous people in the region (Melanesians, Polynesians, Micronesians, Papuans, and Indigenous Australians) are over-represented on national, regional, and global scales for the burden of infectious and non-communicable diseases. Although social and environmental factors such as poverty, education, and access to health-care are assumed to be major drivers of this disease burden, there is also developing evidence that genetic and microbiotic factors should also be considered. To date, studies investigating genetic and/or microbiotic links with vulnerabilities to infectious and non-communicable diseases have mostly focused on populations in Europe, Asia, and USA, with uncertain associations for other populations such as indigenous communities in Oceania. Recent developments in personalized medicine have shown that identifying ethnicity-linked genetic vulnerabilities can be important for medical management. Although our understanding of the impacts of the gut microbiome on health is still in the early stages, it is likely that equivalent vulnerabilities will also be identified through the interaction between gut microbiome composition and function with pathogens and the host immune system. As rapid economic, dietary, and cultural changes occur throughout Oceania it becomes increasingly important that further research is conducted within indigenous populations to address the double burden of high rates of infectious diseases and rapidly rising non-communicable diseases so that comprehensive development goals can be planned. In this article, we review the current knowledge on the impact of nutrition, genetics, and the gut microbiome on infectious diseases in indigenous people of the Pacific region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.