Evidence map›Paper›PMID 31572383›Full record

ArticleFrontiers in immunology2019

Ozone Inhalation Attenuated the Effects of Budesonide on

Cameron H Flayer, Moyar Q Ge, Jin W Hwang, Blerina Kokalari, Imre G Redai, Zhilong Jiang, Angela Haczku

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Air Pollution and Effects of Tropospheric Ozone (OInternational journal of environmental research and public health · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Ozone Exposure and Asthma Attack in Children.Frontiers in pediatrics · 2022
    Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Cameron H FlayerDepartment of Internal Medicine, University of California, Davis, Davis, CA, United States.
Moyar Q GeDepartment of Internal Medicine, University of California, Davis, Davis, CA, United States.
Jin W HwangDepartment of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Blerina KokalariDepartment of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Imre G RedaiDepartment of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Zhilong JiangDepartment of Internal Medicine, University of California, Davis, Davis, CA, United States.
Angela HaczkuDepartment of Internal Medicine, University of California, Davis, Davis, CA, United States.
University of Pennsylvania · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
IND enabling development of LGM2605 as adjuvant treatment for asthmaR42AI132012 · NIAID · LIGNAMED, LLC · PI HACZKU, ANGELA, SIELECKI, THAIS MOTRIA · 2019 to 2021
$3.0M
Mechanisms of social-stress enhanced allergic airway response in a mouse modelR01AI072197 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HACZKU, ANGELA · 2010 to 2014
$2.0M
Effects of ozone exposure on expression and function of surfactant protein DRC1ES018505 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI HACZKU, ANGELA · 2009 to 2010
$1.0M
Asthma, anxiety and GR abnormalities in non-human primatesR21AI116121 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HACZKU, ANGELA · 2015 to 2016
$448k
Effects of LGM2605 on a Primate Model of AsthmaR41AI132012 · NIAID · LIGNAMED, LLC · PI HACZKU, ANGELA, SIELECKI, THAIS MOTRIA · 2017 to 2017
$278k
NHLBI NIH HHS T32 HL007013NIAID NIH HHS R01 AI072197NIAID NIH HHS R21 AI116121NIAID NIH HHS R41 AI132012NIAID NIH HHS R42 AI132012NIEHS NIH HHS P30 ES023513NIEHS NIH HHS RC1 ES018505NIEHS NIH HHS T32 ES007059NIH HHS P51 OD011107
6 · The paper itself

Abstract

Inhaled glucocorticoids form the mainstay of asthma treatment because of their anti-inflammatory effects in the lung. Exposure to the air pollutant ozone (O

Indexed as

A549 CellsAdministration, InhalationAllergensAnimalsAspergillus fumigatusAsthmaBronchoalveolar Lavage FluidBudesonideCells, CulturedChemokine CCL11EosinophilsGlucocorticoidsHumansInflammationInterleukin-13LungAllergensBudesonideChemokine CCL11GlucocorticoidsInterleukin-13Oxidants, PhotochemicalOzonePulmonary Surfactant-Associated Protein Dallergyasthmabudesonideozonesurfactant protein-D

Identifiers

PMID31572383
PMCPMC6753328
OpenAlexW2970066150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.