ReviewFrontiers in endocrinology2019
Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mood Status Response to Physical Activity and Its Influence on Performance: Are Chronotype and Exercise Timing Affect?International journal of environmental research and public health · 2023Pooled it
- A double-blind, randomized, placebo-controlled trial of melatonin as an adjuvant agent for induction of labor: The MILO trial.Acta obstetricia et gynecologica Scandinavica · 2024Trial
- Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin.Frontiers in endocrinology · 2020Trial
- Melatonin and Lactation in Ruminants Dairy Animals: A Systematic Review and Meta-Analysis of Preclinical Studies.Health science reports · 2026Review
- Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology · 2026Article
- Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).Molecular medicine reports · 2026Review
- Article
- Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases.Endocrine journal · 2026Review
- The Impact of Lunar Phases During Day and Night Cycles on Perinatal Outcomes: A Nationwide Cohort Study.Birth (Berkeley, Calif.) · 2026Article
- Time-of-Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin-Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice.Journal of pineal research · 2026Article
- Melatonin is associated with cell-type-specific inflammatory and oxidative stress responses at the maternal-fetal interface.Frontiers in immunology · 2026Article
- Blood Melatonin in Breast Milk-Fed Preterm Infants: Longitudinal Biomonitoring to 38 Weeks' Postmenstrual Age (ProMote Study).Children (Basel, Switzerland) · 2025Article
- The Effects of Meteorological Conditions on the Circadian Rhythm of Births.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Comparative analysis of morning and evening training on performance and well-being in elite soccer players.Physiological reports · 2025Article
- Determination of Natural Blood Plasma Melatonin Concentration of Tsigai Ewes Characteristic for Gestation and Early Postpartum Period Between Autumnal Equinox and Winter Solstice.Veterinary sciences · 2025Article
- Pregnancy as an opportunity to explore brain-immune connections in mental health.Science advances · 2025Review
- Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum.Trends in endocrinology and metabolism: TEM · 2025Review
- Article
- Melatonin modulates the gene expression of WEE1 kinase and clock genes: a crosstalk between the molecular clocks of the placenta?Frontiers in endocrinology · 2025Article
- Social disadvantage is associated with impaired increase in salivary diurnal melatonin amplitude throughout pregnancy.Sleep advances : a journal of the Sleep Research Society · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Pregnancy is influenced by the circadian ("circa" or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles. For example, most species deliver around a particular time of day. In mammals, circadian rhythms are controlled by the master circadian pacemaker, the suprachiasmatic nucleus. One key way that the suprachiasmatic nucleus coordinates circadian rhythms throughout the body is by regulating production of the sleep-promoting hormone melatonin. Serum melatonin concentration, which peaks at night and is suppressed during the day, is one of the best biological indicators of circadian timing. Circadian misalignment causes maternal disturbances in the temporal organization of many physiological processes including melatonin synthesis, and these disturbances of the circadian system have been linked to an increased risk for pregnancy complications. Here, we review evidence that melatonin helps regulate the maternal and fetal circadian systems and the timing of birth. Finally, we discuss the potential for melatonin-based therapeutic strategies to alleviate poor pregnancy outcomes such as preeclampsia and preterm birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.