ArticleFrontiers in psychiatry2019
Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factor associated with the occurrence of epilepsy in autism: a systematic review.Journal of autism and developmental disorders · 2023Pooled it
- Approaches for Predicting the Occurrence of Challenging Behaviors in Individuals with Autism Spectrum Disorder: A Narrative Review.Journal of personalized medicine · 2025Review
- Validity and reliability of the Chinese beliefs about medicines questionnaire-specific in caregivers of children with Epilepsy.Frontiers in public health · 2025Article
- Early life seizures and olfactory communication in rats.Epilepsia · 2024Article
- Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study.Molecular autism · 2024Article
- Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies.Brain sciences · 2020Review
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5 authors.
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Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disease that may involve various brain abnormalities. However, there are few large epidemiological studies on the relation between epilepsy and ASD in terms of different genders and ages. This study aimed to evaluate the relation between epilepsy and ASD based on 74,251 Chinese children aged 3-12 years who were recruited from kindergartens and primary schools in China. ASD was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V), and verification of epilepsy was based on medical records. The enrolled children diagnosed with ASD were examined by magnetic resonance imaging (MRI) and took genetic tests to rule out other neurological and congenital diseases. The raw odds ratio (OR) was 60.53 [95% confidence interval (CI) = 37.80-96.92, P < 0.01] for epilepsy and ASD, and the adjusted OR was 38.99 (95% CI = 20.70-73.41, P < 0.01) after controlling for the confounders. Moreover, the adjusted OR was significantly higher in girls (OR = 45.26, 95% CI = 16.42-124.76, P < 0.01) than in boys (OR = 32.64, 95% CI = 14.33-74.34, P < 0.01). Among children with younger age, the adjusted OR was the highest (OR = 75.12, 95% CI = 22.80-247.48.16, P < 0.01). These findings suggest that epilepsy might be closely linked to the development of ASD, especially for early-onset epilepsy and among girls.
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