Evidence map›Paper›PMID 31572182›Full record

ArticleFrontiers in pharmacology2019

Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner.

Valeria Bortolotto, Heather Bondi, Bruna Cuccurazzu, Maurizio Rinaldi, Pier Luigi Canonico, Mariagrazia Grilli

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Implication of Central βArchiv der Pharmazie · 2025
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  6. Review
  7. The Bioactive Gamma-Oryzanol fromAntioxidants (Basel, Switzerland) · 2024
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  9. Article
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  11. Article
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  13. Article
  14. Article
  15. Observational
  16. Article
  17. βNeural regeneration research · 2021
    Article
  18. Review
  19. Review
  20. Activation of βNeural regeneration research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Valeria BortolottoLaboratory of Neuroplasticity, University of Piemonte Orientale, Novara, Italy.
Heather BondiLaboratory of Neuroplasticity, University of Piemonte Orientale, Novara, Italy.
Bruna CuccurazzuLaboratory of Neuroplasticity, University of Piemonte Orientale, Novara, Italy.
Maurizio RinaldiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy.
Pier Luigi CanonicoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy.
Mariagrazia GrilliLaboratory of Neuroplasticity, University of Piemonte Orientale, Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurogenesis persists in the subgranular zone of the hippocampal formation in the adult mammalian brain. In this area, neural progenitor cells (NPCs) receive both permissive and instructive signals, including neurotransmitters, that allow them to generate adult-born neurons which can be functionally integrated in the preexisting circuit. Deregulation of adult hippocampal neurogenesis (ahNG) occurs in several neuropsychiatric and neurodegenerative diseases, including major depression, and represents a potential therapeutic target. Of interest, several studies suggested that, both in rodents and in humans, ahNG is increased by chronic administration of classical monoaminergic antidepressant drugs, suggesting that modulation of this process may participate to their therapeutic effects. Since the established observation that noradrenergic innervations from locus coeruleus make contact with NPC in the dentate gyrus, we investigated the role of beta adrenergic receptor (β-AR) on ahNG both

Indexed as

adult neurogenesisbeta adrenergic receptorsdoublecortinhippocampusneural progenitor cellsnorepinephrine

Identifiers

PMID31572182
PMCPMC6751403
OpenAlexW2964513997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.