ArticleFrontiers in pharmacology2019
Acute Liver Failure in a Patient Treated With Metamizole.
Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine.British journal of clinical pharmacology · 2022Trial
- Article
- Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users.Drug safety · 2021Article
- Metamizole Has Been Overlooked as a Trigger for Acute Liver Injury and Acute Liver Failure.Deutsches Arzteblatt international · 2020Article
- Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis.Biomedicines · 2020Article
- Liver injury associated with the analgetic drug metamizole.British journal of clinical pharmacology · 2020Article
- Metamizole: An underrated agent causing severe idiosyncratic drug-induced liver injury.British journal of clinical pharmacology · 2020Article
- Dual versus single vessel normothermic ex vivo perfusion of rat liver grafts using metamizole for vasodilatation.PloS one · 2020Article
- Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation.Frontiers in pharmacology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive for metamizole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.