Evidence map›Paper›PMID 31572119›Full record

ArticleFrontiers in neuroscience2019

Structural and Functional Connectivity of the Anterior Cingulate Cortex in Patients With Borderline Personality Disorder.

Xiaoxia Lei, Mingtian Zhong, Bowen Zhang, Huihui Yang, Wanrong Peng, Qian Liu, Yu Zhang, Shuqiao Yao, Changlian Tan, Jinyao Yi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
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  9. Article
  10. Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiaoxia LeiMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Mingtian ZhongCenter for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
Bowen ZhangCenter for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
Huihui YangMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Wanrong PengMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Qian LiuCenter for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
Yu ZhangCenter for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.
Shuqiao YaoMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Changlian TanDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jinyao YiMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSouth China Normal University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidences supported the hypothesis that emotional dysregulation results from aberrant connectivity within the fronto-limbic neural networks in patients with borderline personality disorder (BPD). Considering its important role in emotional regulation, the anterior cingulate cortex (ACC) has not yet been fully explored in BPD patients. Therefore, using the seed-based resting state functional connectivity (rsFC) and probabilistic fiber tracking, we aimed to explore the alterations of functional and structural connectivity (SC) of the ACC in patients with BPD.

methodsA cohort of 50 unmedicated, young BPD patients and 54 sex-, age-, and education-matched healthy controls (HCs) completed psychological tests and underwent rs-fMRI and diffuse tensor imaging (DTI) scanning. Rs-FC analysis and probabilistic fiber tracking were used to plot SC and FC of the ACC.

resultsWith the left ACC selected as a seed, BPD patients exhibited increased rsFC and abnormal SC with the right middle frontal gyrus (MFG), and decreased rsFC with the left middle temporal gyrus (MTG), compared with HCs. Additionally, negative cognitive emotion regulation and depressive symptoms both correlated negatively with the rsFC of the left ACC in BPD patients.

conclusionAbnormal SC and FC of the ACC underlie the deficient emotional regulation circuitry in BPD patients. Such alterations may be important biomarkers of BPD and thus could point to potential BPD treatment targets.

Indexed as

anterior cingulate cortexborderline personality disorderemotionprobabilistic fiber trackingresting state functional connectivity

Identifiers

PMID31572119
PMCPMC6753388
OpenAlexW2970576145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.