ArticleNeuropsychiatric disease and treatment2019
Differentiation Between Dementia With Lewy Bodies And Alzheimer's Disease Using Voxel-Based Morphometry Of Structural MRI: A Multicenter Study.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Automated Imaging Differentiation for Dementia: Including Alzheimer Disease Dementia and Dementia with Lewy Bodies.Neurology open access · 2026Article
- Seven tesla MRI reveals amygdala and hippocampal subfield atrophy in dementia with Lewy bodies.Alzheimer's research & therapy · 2026Article
- Statistical Parametric Mapping and Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD): Principles and Clinical Applications.Brain sciences · 2025Review
- Voxel-based Specific Regional Analysis System for Alzheimer’s Disease and Arterial Spin Labeling in Brain Magnetic Resonance Imaging: A Comparative StudyCurrent medical imaging · 2025Article
- SynthSR-generated 3D T1-weighted MRI from routine 2D clinical images: Validation for VSRAD analysis.Frontiers in neurology · 2025Article
- The Role of Gastrointestinal Dysbiosis and Fecal Transplantation in Various Neurocognitive Disorders.Cureus · 2024Review
- The usefulness of combined analysis using CIScore and VSRAD parameters for differentiating between dementia with Lewy body and Alzheimer's disease.Japanese journal of radiology · 2024Article
- Differential diagnosis of MCI with Lewy bodies and MCI due to Alzheimer's disease by visual assessment of occipital hypoperfusion on SPECT images.Japanese journal of radiology · 2024Article
- Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology · 2022Review
- Voxel-based specific regional analysis system for Alzheimer's disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study.Journal of diabetes investigation · 2022Article
- Motion correction in MR image for analysis of VSRAD using generative adversarial network.PloS one · 2022Article
- Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Article
- Voxel-Based Morphometry Analysis of Structural MRI for Differentiation Between Dementia with Lewy Bodies and Alzheimer's Disease [Letter].Neuropsychiatric disease and treatment · 2020Article
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21 authors at 12 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) is particularly important because DLB patients respond better to cholinesterase inhibitors but sometimes exhibit sensitivity to neuroleptics, which may cause worsening of clinical status. Antemortem voxel-based morphometry (VBM) using structural MRI has previously revealed that patients with DLB have normal hippocampal volume, but atrophy in the dorsal mesopontine area.
objectivesThe aim of this multicenter study was to determine whether VBM of the brain stem in addition to that of medial temporal lobe structures improves the differential diagnosis of AD and DLB.
methodsWe retrospectively chose 624 patients who were clinically diagnosed with either DLB (239 patients) or AD (385 patients) from 10 institutes using different MR scanners with different magnetic field strengths. In all cases, VBM was performed on 3D T1-weighted images. The degree of local atrophy was calculated using Z-score by comparison with a database of normal volumes of interest (VOIs) in medial temporal lobe (MTL) and the dorsal brain stem (DBS). The discrimination of DLB and AD was evaluated using Z-score values in these two VOIs. MRI data from 414 patients were used as the training data set to determine the classification criteria, with the MRI data from the remaining 210 patients used as the test data set.
resultsThe DLB and AD patients did not differ with respect to mean age or Mini-Mental State Examination scores. Z-index scores showed that there was significantly more atrophy in MTL of AD patients, compared to DLB patients and in DBS of DLB patients, compared to AD patients. The discrimination accuracies of VBM were 63.3% in the test data set and 73.4% in the training data set.
conclusionVBM of DBS in addition to that of MTL improves the differentiation of DLB and AD.
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