Evidence map›Paper›PMID 31571880›Full record

ArticleNeuropsychiatric disease and treatment2019

Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder.

Shao-Wei Xue, Donglin Wang, Zhonglin Tan, Yan Wang, Zhenzhen Lian, Yunkai Sun, Xiaojiao Hu, Xiaole Wang, Xin Zhou

Abstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shao-Wei XueCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Donglin WangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Zhonglin TanDepartment of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou 310013, People's Republic of China.
Yan WangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Zhenzhen LianCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Yunkai SunCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Xiaojiao HuCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Xiaole WangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
Xin ZhouCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEntropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnormal changes in the thalamus based on R-fMRI are still unclear from the perspective of brain temporal dynamics. The aim of this study was to identify local entropy changes and subregional connectivity patterns of the thalamus in MDD patients. PATIENTS AND

methodsWe measured the sample entropy of the R-fMRI data from 46 MDD patients and 32 matched healthy controls. We employed the Louvain method for the module detection algorithm to automatically identify a functional parcellation of the thalamus and then examined the whole-brain subregional connectivity patterns.

resultsThe results indicated that the MDD patients had decreased entropy in the bilateral thalami compared with healthy controls. Increased functional connectivity between the thalamic subregions and the medial part of the superior frontal gyrus (mSFG) was found in MDD patients.

conclusionThis study showed new evidence about sample entropy changes in MDD patients. The functional connectivity alterations that were widely distributed across almost all the thalamic subregions with the mSFG in MDD suggest a general involvement independent of the location and function of the subregions.

Indexed as

entropyfunctional connectivitymajor depressive disordersuperior frontal gyrusthalamus

Identifiers

PMID31571880
PMCPMC6750201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.