Evidence map›Paper›PMID 31571874›Full record

ArticleInternational journal of nanomedicine2019

Investigation Of Vitamin B

Lingli Long, Minghua Lai, Xuhong Mao, Jiahao Luo, Xin Yuan, Li-Ming Zhang, Zunfu Ke, Liqun Yang, David Yb Deng

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Mucoadhesive carriers for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
  6. Review
  7. Review
  8. Bile acid transporter-mediated oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lingli Long *Department of Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People's Republic of China.
Minghua Lai *Department of Polymer and Material Science, School of Chemistry, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Provincial Key Laboratory for High Performance Polymer-based Composites, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
Xuhong MaoFaculty of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
Jiahao LuoDepartment of Polymer and Material Science, School of Chemistry, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Provincial Key Laboratory for High Performance Polymer-based Composites, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
Xin YuanDepartment of Scientific Research Center and Orthopedic, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, People's Republic of China.
Li-Ming ZhangFaculty of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
Zunfu KeDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People's Republic of China.ORCID 0000-0002-6251-7246
Liqun YangDepartment of Polymer and Material Science, School of Chemistry, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Provincial Key Laboratory for High Performance Polymer-based Composites, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
David Yb DengDepartment of Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People's Republic of China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeptide drugs have been used in therapy various diseases. However, the poor bioavailability of peptide drugs for oral administration has limited their clinical applications, on account of the acidic environment and digestive enzymes inside the human gastrointestinal tract. To enhance stability in the human gastrointestinal tract, bioavailability, and targeted drug delivery of peptide drugs through oral administration, a vitamin B MATERIALS AND

methodsA vitamin B

resultsThey were observed as spherical nanoparticles in the size of 30-50 nm. The CSAD-VB

conclusionCSAD-VB

Indexed as

Drug Delivery SystemsAdministration, OralAlginatesAnimalsCaco-2 CellsCell DeathCell Membrane PermeabilityCell SurvivalDiabetes Mellitus, ExperimentalDrug LiberationEndocytosisFemaleHumansInsulinIntestinal AbsorptionMaleAlginatesInsulinPeptidesPharmaceutical PreparationsVitamin B 12human colon adenocarcinoma cellinsulinnanoparticlesmall intestinal absorption efficacy

Identifiers

PMID31571874
PMCPMC6760826
OpenAlexW2973935451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.