ArticleInternational journal of nanomedicine2019
Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention.
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Macrophages bend long fibres with flexural rigidity lower than 3 mN·nmParticle and fibre toxicology · 2026Article
- Nano-Modified Titanium Implant Surfaces for the Prevention and Treatment of Peri-Implantitis: A Review.International journal of nanomedicine · 2026Review
- Nanocomposite orthopaedic bone cement combining long-acting dual antimicrobial drugs.Biomaterials advances · 2023Article
- Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation.Frontiers in bioengineering and biotechnology · 2022Review
- Smart Coatings Prepared via MAPLE Deposition of Polymer Nanocapsules for Light-Induced Release.Molecules (Basel, Switzerland) · 2021Article
- Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacyDrug delivery · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe only treatment for aseptic loosening is the replacement of the prosthesis through revision surgery. A preventive approach, achieved through anti-inflammatory drugs released from the device, has shown to be a viable strategy; however, the performance of these devices is not yet satisfactory thus further improvements are necessary.
methodsWe used titanium nanoparticles as a model for implant surfaces and developed a coating containing dexamethasone (DEX) using layer-by-layer deposition.
resultsThe amount of deposited drug depended on the number of layers and the release was sustained for months. The efficiency of the released DEX in reducing inflammation markers (tumor necrosis factor alpha and IL-6) produced by human monocytes and macrophages was similar to the pure drug at the same concentration without negative impacts on the viability and morphology of these cells.
conclusionThese coatings were not inferior to medical grade titanium (the standard material used in uncemented devices) regarding their ability to sustain osteoblasts and fibroblasts growth.
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Registered trials
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