Evidence map›Paper›PMID 31571815›Full record

ReviewClinical ophthalmology (Auckland, N.Z.)2019

Macular edema associated with non-infectious uveitis: pathophysiology, etiology, prevalence, impact and management challenges.

Horace Massa, Spyros Y Pipis, Temilade Adewoyin, Athanasios Vergados, Sudeshna Patra, Georgios D Panos

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Clinical ophthalmology (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06686641 (Incidence of Macular Edema in a Uveitis Population of 1500 Patients), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06686641 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Incidence of Macular Edema in a Uveitis Population of 1500 Patients

Typeobservational_patient_registrySponsorAalborg University HospitalRan2024 to 2025Enrolled1,550ConditionsMacular Edema, Non-infectious UveitisArmsLocal and systemical treatment
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 64 citations in OpenAlex.

  1. Adalimumab biosimilars compared to originator: impact on uveitic macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Systemic immunosuppressive therapy in idiopathic non-infectious uveitis and scleritis: disease remission, discontinuation, and relapse patterns.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. miR‑205: A dual regulator of angiogenesis in health and disease (Review).International journal of molecular medicine · 2026
    Review
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  16. Increased vitreous levels of B cell activation factor (BAFF) and soluble interleukin-6 receptor in patients with macular edema due to uveitis related to Behçet's disease and sarcoidosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  17. Sarcoid Uveitis: An Intriguing Challenger.Medicina (Kaunas, Lithuania) · 2022
    Review
  18. Optical coherence tomography angiography in intermediate uveitis-related cystoid macular edema.Medical hypothesis, discovery & innovation ophthalmology journal · 2022
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Horace Massa *Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.
Spyros Y Pipis *Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Temilade AdewoyinEye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Athanasios VergadosEye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Sudeshna PatraEye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Georgios D Panos *Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Barts Health NHS Trust · GBUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macular edema (ME) is the most common sight-threatening complication in uveitis. The diagnostic and therapeutic management of the uveitic macular edema (UME) might be challenging due to the complex diagnostic workup and the difficulties physicians face to find the underlying cause, and due to its usually recurrent nature and the fact that it can be refractory to conventional treatment. Some of the mild cases can be treated with topical steroids, which can be combined with non-steroid anti-inflammatory drugs. However, immunomodulators such as methotrexate, tacrolimus, azathioprine, cyclosporine and mycophenolate mofetil together with anti-tumor necrosis factor-α (anti-TNF alpha) monoclonal antibodies such as adalimumab and infliximab, may be required to control the inflammation and the associated ME in refractory cases, or when an underlying disease is present. This review of the literature will focus mostly on the non-infectious UME.

Indexed as

anti-TNF alphacorticosteroidsimmunomodulatorsmacular edemanon-infectious uveitisNSAIDs

Identifiers

PMID31571815
PMCPMC6750710
OpenAlexW2972463138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.