ArticleActa Cardiologica Sinica2019
Association of Epicardial Adipose Tissue Thickness with Extent and Complexity of Coronary Artery Disease in Patients with Acute Coronary Syndrome.
Article in Acta Cardiologica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration.International journal of molecular sciences · 2024Review
- Non-Alcoholic Fatty Pancreas Disease is Associated with SYNTAX Score in Acute Coronary Syndrome.Acta Cardiologica Sinica · 2022Article
- Prediction of Lipoprotein-Associated Phospholipase A2 and Inflammatory Markers in Subclinical Atherosclerosis in Premature Ovarian Failure Patients.Acta Cardiologica Sinica · 2021Article
- Considering ISCHEMIA in the Context of FAME and FAME 2: A Call for the Universal Adoption of Invasive Ischemia-Guided Coronary Intervention Approach in Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2020Article
- Relationship between Epicardial Adipose Tissue Thickness Measured by Computed Tomography and Coronary Thrombus Burden in Patients with ST-elevation Myocardial Infarction.Journal of cardiovascular echographyArticle
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Abstract
backgroundEpicardial adipose tissue (EAT) secretes proatherogenic and proinflammatory cytokines and affects cardiac morphology and functions. The aim of this study was to measure EAT thickness in patients without previous coronary artery disease (CAD) who were admitted with acute coronary syndrome (ACS), and determine its relationship to ACS clinical risk scores, and the severity and complexity of CAD.
methodsThis study enrolled 150 patients (mean age 59.7 ± 11.1 years, 83% men), including 75 with non-ST elevated myocardial infarction (NSTEMI group) and 75 with ST elevated myocardial infarction (STEMI group). Cardiovascular risk factors and laboratory analyses were recorded. The Global Registry of Acute Coronary Events (GRACE) risk score, TIMI clinical, SYNTAX and Gensini angiographic scores were calculated according to guidelines. EAT thickness was measured by echocardiography above the free wall of the right ventricle, perpendicular to the aortic annulus.
resultsThere were no significant differences in CAD risk factors, clinical, demographic features, anthropometric measurements, or EAT thickness (mean 5.94 ± 1.17 mm) between the two groups. In the patients with ACS, there were no direct correlations between EAT thickness and TIMI, GRACE, SYNTAX and Gensini scores. There were positive and significant correlations between the thickness of EAT and SYNTAX (r = 0.243, p = 0.035) and Gensini (r = 0.394, p < 0.001) scores only in the NSTEMI group. Multivariate linear regression analysis showed that EAT predicted SYNTAX (β = 0.06, p < 0.001) and Gensini (β = 0.04, p = 0.006) scores, but not TIMI score (β = 0.1, p = 0.06) in the patients overall.
conclusionsEAT thickness measured by 2D echocardiography was not correlated with the extent or complexity of CAD in the ACS patients. However, after adjusting for confounding factors, multivariate linear regression analysis showed that EAT predicted SYNTAX and Gensini scores in these patients.
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