ArticleIndian journal of nephrology
Thrombotic Microangiopathy: An Under-Recognised Cause of Snake-bite-related Acute Kidney Injury.
Article in Indian journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Snakebite associated thrombotic microangiopathy: a systematic review of clinical features, outcomes, and evidence for interventions including plasmapheresis.PLoS neglected tropical diseases · 2020Pooled it
- The kidney histopathological spectrum of patients with kidney injury following snakebite envenomation in India: scoping review of five decades.BMC nephrology · 2024Article
- Cortical Blindness and Thrombotic Microangiopathy Following a Hemotoxic Snake Envenomation: An Unusual Presentation.Cureus · 2023Article
- Thrombotic Microangiopathy: An Under-Recognized Cause of CKD Following Viper Envenomation.Kidney international reports · 2022Article
- Case Report: Delayed Diffuse Alveolar Hemorrhage in Echis sochureki Envenoming, Jodhpur, India.The American journal of tropical medicine and hygiene · 2022Article
- Snakebite Associated Thrombotic Microangiopathy and Recommendations for Clinical Practice.Toxins · 2022Review
- Snake bite associated with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2021Review
- Schistocyte quantitation, thrombotic microangiopathy and acute kidney injury in Australian snakebite coagulopathy [ASP28].International journal of laboratory hematology · 2021Article
- Role of extracorporeal therapy in poisoning - A case based narrative.International journal of critical illness and injury scienceArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThrombotic microangiopathy (TMA) as a cause of snake-bite-induced acute kidney injury (AKI) is rarely reported. Very little is known about the clinical course, optimal management, and prognosis of this entity. We describe a series of snake-bite-induced TMA and compare their outcomes with those without TMA.
methodsThis was a single-center retrospective study of patients with AKI following snake envenomation admitted between January 2012 and December 2017. Demographic profile, clinical parameters, and outcomes were studied. TMA was diagnosed based on presence of triad of microangiopathic hemolytic anemia, thrombocytopenia, and AKI, and groups with and without TMA were compared.
resultsOf 103 patients with AKI following snake bite, 19 (18.5%) had clinical evidence of TMA. All patients with TMA had advanced azotemia (mean peak serum creatinine 9.5 ± 3.0 mg/dL), with 18 (95%) requiring renal replacement therapy (RRT). Thirteen (68%) had either complete or partial recovery of renal functions, two (10%) progressed to end-stage renal disease, and one died (three patients were lost to follow-up). Age ≥50 years, presence of oliguria/anuria, anti-snake venom dose ≥10 vials, and urea ≥80 mg/dL at presentation were independently associated with TMA (
conclusionsIn conclusion, TMA was seen in 18.5% of patients with snake-bite-related AKI in our study and was associated with almost universal need for RRT, longer duration on RRT, and hospital stay compared with patients without TMA.
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