ArticleNeural regeneration research2020
Animal models used to study direct peripheral nerve repair: a systematic review.
Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.Regenerative medicine · 2024Pooled it
- A systematic review and meta-analysis of studies comparing muscle-in-vein conduits with autologous nerve grafts for nerve reconstruction.Scientific reports · 2021Pooled it
- Neuroma Prevention with a Novel In Situ Forming Hydrogel in a Rat Sciatic Nerve Model.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value.International journal of molecular sciences · 2025Review
- Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.Progress in biomedical engineering (Bristol, England) · 2025Review
- Nerve Tape Is an Effective Tool for Small Nerve Repair.Plastic and reconstructive surgery. Global open · 2025Article
- Review of Gaps in the Clinical Indications and Use of Neural Conduits and Artificial Grafts for Nerve Repair and Reconstruction.Biomacromolecules · 2025Review
- Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model.Journal of neuroengineering and rehabilitation · 2025Article
- Gelatin-Based Hydrogels for Peripheral Nerve Regeneration: A Multifunctional Vehicle for Cellular, Molecular, and Pharmacological Therapy.Gels (Basel, Switzerland) · 2025Review
- The Use of Grayscale Muscle Ultrasound to Indicate Muscle Recovery after Peripheral Nerve Reconstruction.Plastic and reconstructive surgery · 2025Article
- Selection of sciatic nerve injury models: implications for pathogenesis and treatment.Frontiers in neurology · 2025Review
- A stretchable, electroconductive tissue adhesive for the treatment of neural injury.Bioengineering & translational medicine · 2024Article
- Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration.Biophysical reviews · 2024Review
- Interactions of Cells and Biomaterials for Nerve Tissue Engineering: Polymers and Fabrication.Polymers · 2023Review
- Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy.Neurophotonics · 2023Article
- Bridging Gaps in Peripheral Nerves: From Current Strategies to Future Perspectives in Conduit Design.International journal of molecular sciences · 2023Review
- Mesenchymal Stem Cells in Nerve Tissue Engineering: Bridging Nerve Gap Injuries in Large Animals.International journal of molecular sciences · 2023Review
- Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Hindlimb muscle spindles inform preparatory forelimb coordination prior to landing in toads.The Journal of experimental biology · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeripheral nerve repair is required after traumatic injury. This common condition represents a major public health problem worldwide. Recovery after nerve repair depends on several factors, including the severity of the injury, the nerve involved, and the surgeon's technical skills. Despite the precise microsurgical repair of nerve lesions, adequate functional recovery is not always achieved and, therefore, the regeneration process and surgical techniques are still being studied. Pre-clinical animal models are essential for this research and, for this reason, the focus of the present systematic review (according to the PRISMA statement) was to analyze the different animal models used in pre-clinical peripheral nerve repair studies. DATA SOURCES: Original articles, published in English from 2000 to 2018, were collected using the Web of Science, Scopus, and PubMed databases. DATA SELECTION: Only preclinical trials on direct nerve repair were included in this review. The articles were evaluated by the first two authors, in accordance with predefined data fields. OUTCOME MEASURES: The primary outcomes included functional motor abilities, daily activity and regeneration rate. Secondary outcomes included coaptation technique and animal model.
resultsThis review yielded 267 articles, of which, after completion of the screening, 49 studies were analyzed. There were 1425 animals in those 49 studies, being rats, mice, guinea pigs, rabbits, cats and dogs the different pre-clinical models. The nerves used were classified into three groups: head and neck (11), forelimb (8) and hindlimb (30). The techniques used to perform the coaptation were: microsuture (46), glue (12), laser (8) and mechanical (2). The follow-up examinations were histology (43), electrophysiological analysis (24) and behavioral observation (22).
conclusionThe most widely used animal model in the study of peripheral nerve repair is the rat. Other animal models are also used but the cost-benefit of the rat model provides several strengths over the others. Suture techniques are currently the first option for nerve repair, but the use of glues, lasers and bioengineering materials is increasing. Hence, further research in this field is required to improve clinical practice.
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