Observational studyEuropean journal of cancer care2020
Patients with head and neck cancer: Are they frailer than patients with other solid malignancies?
Observational study in European journal of cancer care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sarcopenia, frailty syndrome and obstructive sleep apnea as elements of the aging phenotype in head and neck cancer and upper airway disorders: a scoping review.Frontiers in medicine · 2026Pooled it
- Pooled it
- Latent profiles of frailty in patients with head and neck cancer undergoing radiotherapy: a cross-sectional study.BMJ open · 2026Article
- Does Modified 5-Item Frailty Index Correlate With Survival in Oropharyngeal Squamous Cell Carcinoma?Head & neck · 2026Article
- Multidimensional Prognostic Index as a Predictor of Mortality in Head and Neck Cancer Patients: A Cohort Study.Head & neck · 2025Observational
- The impact of a patient decision aid for patients with advanced laryngeal carcinoma - a multicenter study.BMC medical informatics and decision making · 2025Article
- Impact of Frailty on Post-Treatment Dysphagia in Patients with Head and Neck Cancer.Dysphagia · 2025Article
- Unveiling the relation between swallowing muscle mass and skeletal muscle mass in head and neck cancer patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Pre-Treatment Serum Prognostic Scores and Survival in Curatively Treated Laryngeal Cancer.Laryngoscope investigative otolaryngology · 2025Article
- ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): a feasibility study investigating a patient-centred approach to exercise for head and neck cancer patients.Frontiers in oncology · 2025Article
- Impact of Preoperative Multidisciplinary Conference on Head and Neck Reconstruction Outcomes.The Laryngoscope · 2025Article
- The role of prehabilitation in HNSCC patients treated with chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Evaluation of a new two-step frailty assessment of head and neck patients in a prospective cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Factors influencing physical activity in individuals with head and neck cancer: a scoping review.BMJ open · 2024Article
- Head and neck cancer patients with geriatric deficits are more often non-responders and lost from follow-up in quality of life studies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Frailty is an independent factor for health-related quality of life in patients with head and neck cancer receiving definitive concurrent chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC).Journal of clinical medicine · 2023Article
- Association of Tumor Microenvironment with Biological and Chronological Age in Head and Neck Cancer.Cancers · 2023Article
- Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Insight on common forms of cutaneous head and neck carcinoma (Review).Molecular and clinical oncology · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to compare frailty status between patients with head and neck cancer (HNC) and other solid malignancies.
methodsData collection was prospective, and the following were compared between cohorts at baseline: patient and tumour characteristics, Charlson Comorbidity Index (CCI), Groningen Frailty Indicator (GFI), Mini Mental State Examination (MMSE), Activities of Daily Living (ADLs), Instrumental ADLs (IADLs), Timed Up and Go (TUG) and Quality of Life (QoL). Univariate and multivariate logistic regression analyses were performed, and odds ratios (ORs) with their 95% confidence intervals (95% CIs) were estimated.
resultsIn total, 242 patients with HNC and 180 with other oncology diagnoses were enrolled, of whom 32.6% and 21.8% were frail according to the GFI respectively. Comorbidity scores were not significantly different between the cohorts (7.4% vs. 13.1%; OR 0.54; 95% CI 0.28-1.02). In the univariate analysis, the GFI was significantly worse in the HNC cohort (OR 1.74; 95% CI 1.11-2.71). However, in the multivariate analysis, the MMSE, TUG and global QoL were significantly worse in the HNC cohort, with ORs of 20.03 (95% CI 2.44-164.31), 11.56 (95% CI 1.86-71.68) and 0.98 (95% CI 0.97-1.00) respectively.
conclusionPatients with HNC appear to be frailer than patients with other solid malignancies despite comparable levels of comorbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.