ArticleThe Plant journal : for cell and molecular biology2020
Degradation of the transcription factors PIF4 and PIF5 under UV-B promotes UVR8-mediated inhibition of hypocotyl growth in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 89 citations in OpenAlex.
- The OsUVR8-OsNAC3-OsERF117 signaling module mediates metabolic acclimation and climate adaptation in rice.Science advances · 2026Article
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Functional evolution and rewiring of the UVR8-BES1/BIM1 module underpin the refinement of UV-B responses during plant terrestrialization.Plant communications · 2026Article
- PIF4 enhances temperature-independent tolerance to TSWV in Nicotiana benthamiana.Scientific reports · 2026Article
- Conservation and divergence of UVR8 photoreceptor-mediated UV-B signaling in Marchantia polymorpha.Plant physiology · 2026Article
- Prefoldin 3 promotes the turnover of WRKY70 and FHY3 to modulate UV-B-induced hypocotyl growth inhibition in Arabidopsis thaliana.Plant communications · 2026Article
- Integration of light quality signals regulates ABA abundance and stomatal movements during seedling establishment.The New phytologist · 2026Article
- Mechanisms of acclimation regulation and stress response to UV-B inFrontiers in plant science · 2026Article
- Plant tolerance mechanisms to DNA-damaging UV stress.Journal of experimental botany · 2025Review
- Effects of Continuous Low-Level UV-B, Alone or in Combination with Blue Light, on Photosynthetic and Antioxidant Responses of Morphologically Distinct Red-Leaf Lettuce Cultivars.Plants (Basel, Switzerland) · 2025Article
- Morphological responses of Arabidopsis thaliana wild type and photoreceptor genotypes to narrowband UV radiation generated by LEDs.Plant biology (Stuttgart, Germany) · 2025Article
- Sensory Perception of Fluctuating Light in Arabidopsis.Plant, cell & environment · 2025Article
- CRY1-GAIP1 complex mediates blue light to hinder the repression of PIF5 on AGL5 to promote carotenoid biosynthesis in mango fruit.Plant biotechnology journal · 2025Article
- UV-B increases active phytochrome B to suppress thermomorphogenesis and enhance UV-B stress tolerance at high temperatures.Plant communications · 2025Article
- Metabolomic Analysis ofMolecules (Basel, Switzerland) · 2024Article
- Photoreceptor-induced sinapate synthesis contributes to photoprotection in Arabidopsis.Plant physiology · 2024Article
- Article
- Comprehensive Transcriptome and Proteome Analyses Reveal the Drought Responsive Gene Network in Potato Roots.Plants (Basel, Switzerland) · 2024Article
- Functional divergence of Arabidopsis REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 and 2 in repression of flowering.Plant physiology · 2024Article
- Phytochrome-Interacting Proteins.Biomolecules · 2023Review
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3 authors at 1 institution in 1 country.
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Abstract
Inhibition of hypocotyl growth is a well-established UV-B-induced photomorphogenic response that is mediated by the UV-B photoreceptor UV RESISTANCE LOCUS 8 (UVR8). However, the molecular mechanism by which UVR8 signaling triggers inhibition of hypocotyl growth is poorly understood. The bZIP protein ELONGATED HYPOCOTYL 5 (HY5) functions as the main positive regulatory transcription factor in the UVR8 signaling pathway, with HY5-HOMOLOG (HYH) playing a minor role. However, here we demonstrate that hy5 hyh double mutants maintain significant UVR8-dependent hypocotyl growth inhibition. We identify UVR8-dependent inhibition of the activities of bHLH transcription factors PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and PIF5 as part of the UVR8 signaling pathway, which results in inhibition of hypocotyl growth. The UVR8-mediated repression of several hypocotyl elongation-related genes is independent of HY5 and HYH but largely associated with UVR8-dependent degradation of PIF4 and PIF5, a process that consequently diminishes PIF4/5 target promoter occupancy. Taken together, our data indicate that UVR8-mediated inhibition of hypocotyl growth involves degradation of PIF4 and PIF5. These findings contribute to our mechanistic understanding of UVR8-induced photomorphogenesis and further support the function of PIFs as integrators of different photoreceptor signaling pathways.
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