Evidence map›Paper›PMID 31571111›Full record

ArticleMolecular biology reports2019

Promoter activity of earthworm metallothionein in mouse embryonic fibroblasts.

Victoria Drechsel, Birgit Fiechtner, Martina Höckner

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Victoria DrechselInstitute of Zoology, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria.
Birgit FiechtnerInstitute of Zoology, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria.
Martina HöcknerInstitute of Zoology, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria. martina.hoeckner@uibk.ac.at.ORCID http://orcid.org/0000-0001-8093-3756
Universität Innsbruck · AT

Funding

Universität Innsbruck ID 235916
6 · The paper itself

Abstract

The regulation of metallothionein (MT) gene expression as important part of the detoxification machinery is only scarcely known in invertebrates. In vertebrates, MT gene activation is mediated by the metal-transcription factor 1 (MTF-1) binding to metal response elements (MREs). In invertebrates, the mechanisms of MT gene activation seems to be more diverse. In some invertebrate species, MTF-1 orthologues as well as their ability to activate MT genes via MREs have been uncovered. Although earthworm MTs have been well studied, a MTF-1 orthologue has not yet been described and MT gene activation mechanisms are largely unknown. Analyses of the earthworm wMT2 promoter by reporter gene assays have been performed. We could show that the wMT2 promoter was active in mouse embryonic fibroblasts (NIH/3T3) as well as in mouse MTF-1

Indexed as

AnimalsCadmiumCell LineCell ProliferationDNA-Binding ProteinsFibroblastsGenes, ReporterMetallothioneinMiceNIH 3T3 CellsOligochaetaPromoter Regions, GeneticTranscriptional ActivationTranscription Factor MTF-1Transcription FactorsTransfectionCadmiumDNA-Binding ProteinsMetallothioneinTranscription Factor MTF-1Transcription FactorsZincEarthwormGene regulationMetallothioneinMTF-1Reporter gene assay

Identifiers

PMID31571111
OpenAlexW2977853509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.