ArticleDigestive diseases and sciences2020
Cholangioscopy Biopsies Improve Detection of Cholangiocarcinoma When Combined with Cytology and FISH, but Not in Patients with PSC.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical Validation of AI-Assisted Evaluation of Indeterminate Biliary Strictures in Digital-Single Operator Cholangioscopy: A Transcontinental Multicentric Study.Clinical and translational gastroenterology · 2026Article
- Evolving techniques to optimize ERCP-based sampling and evaluation of malignant biliary strictures.Gastroenterology report · 2026Review
- A retrospective evaluation of preemptive liver transplantation for bile duct dysplasia in primary sclerosing cholangitis: Balancing risks and benefits.JHEP reports : innovation in hepatology · 2025Article
- Current insights and future perspectives of treatment strategies for biliary tract cancer.World journal of gastrointestinal oncology · 2025Review
- Advances in Endoscopic Diagnosis and Management of Cholangiocarcinoma.Journal of clinical medicine · 2025Review
- The incidence and predictors of false-negative pancreatobiliary fluorescence in situ hybridization (PB-FISH) in biliary strictures: A prospective study.Hepatology communications · 2025Observational
- Morphologic and molecular diagnostic criteria of malignancies in biliary strictures.Histology and histopathology · 2025Review
- Contribution of the EyeMAX™ 11Fr (Micro-Tech) digital single-operator cholangioscope with a wide working channel: a multicenter pilot study on the first French experiences.Therapeutic advances in gastroenterology · 2025Article
- Per-oral cholangioscopy in patients with primary sclerosing cholangitis: a 12-month follow-up study.Endoscopy international open · 2024Article
- Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma: From Pathogenesis to Diagnostic and Surveillance Strategies.Cancers · 2023Review
- Histological assessment of new cholangioscopy-guided forceps in ERCP biliary stricture sampling: a blinded comparative study.Endoscopy international open · 2022Article
- Advanced Imaging of the Biliary System and Pancreas.Digestive diseases and sciences · 2022Review
- Peroral cholangioscopy: Update on the state-of-the-art.World journal of gastrointestinal endoscopy · 2022Article
- Rapid label-free detection of cholangiocarcinoma from human serum using Raman spectroscopy.PloS one · 2022Article
- Choledochoscopy: An update.World journal of gastrointestinal endoscopy · 2021Review
- Tips and tricks for the diagnosis and management of biliary stenosis-state of the art review.World journal of gastrointestinal endoscopy · 2021Review
- Refined pancreatobiliary UroVysion criteria and an approach for further optimization.Cancer medicine · 2021Article
- Applications, Limitations, and Expansion of Cholangioscopy in Clinical Practice.Gastroenterology & hepatology · 2021Article
- Role of Endoscopy in Primary Sclerosing Cholangitis.Clinical endoscopy · 2021Review
- Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies.World journal of hepatology · 2021Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSingle-operator cholangioscopy (SOC) has been suggested to be a cost-effective strategy for the detection of cholangiocarcinoma (CCA). The aim of this study is to compare the performance characteristics of SOC-guided biopsies and transpapillary biopsies with standard sampling techniques for the detection of CCA.
methodsA retrospective cohort study of patients undergoing SOC between 1/2007 and 10/2018 at a single academic center was performed. Demographic, procedural, and outcomes data were recorded and analyzed using STATA 14.0. Sensitivity comparison between diagnostic tests was performed using exact McNemar test exclusively among patients with CCA. Two-sided p value < 0.05 was considered statistically significant.
resultsNinety-two patients were included; 36 (39.1%) with primary sclerosing cholangitis (PSC), 41 (44.6%) with CCA, and median follow-up was 15.1 months. In the overall cohort, brush cytology demonstrated a sensitivity of 44.7% and increased with the addition of FISH (56.8%; p = 0.12), FISH with SOC-guided biopsy (71.4%; p = 0.03), and FISH with transpapillary biopsy (64.5%; p = 0.01). However, in patients with PSC, there was no significant improvement in sensitivity with the addition of SOC-guided biopsy or transpapillary biopsy in addition to FISH when compared to brush cytology. There was no difference in the rates of overall adverse events (14% vs. 23.2%; p = 0.27) or infection (3% vs. 4%; p = 0.83) in patients with and without PSC.
conclusionsSOC-guided and transpapillary biopsies improve sensitivity for the detection of cholangiocarcinoma in combination with other ERCP-based techniques compared to brush cytology alone. However, while safe, these modalities do not significantly improve the sensitivity for the detection of malignancy in PSC patients.
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