ArticleEuropean archives of psychiatry and clinical neuroscience2020
Increased cerebellar-default-mode network connectivity at rest in obsessive-compulsive disorder.
Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis and meta-regression of diagnostic test accuracy of connectome-based predictive modeling in OCD.Brain imaging and behavior · 2026Pooled it
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- A comprehensive review for machine learning on neuroimaging in obsessive-compulsive disorder.Frontiers in human neuroscience · 2023Pooled it
- Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Resting-state local brain functional synchronization after a single trigger-zone stimulation: with versus without evoked pain in classical trigeminal neuralgia patients.The journal of headache and pain · 2026Article
- Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2025Article
- Functional Coupling between the Fronto-Parietal Network and Default Mode Network Is Associated with Balanced Time Perspective.Brain sciences · 2022Article
- Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive-Compulsive Disorder.Brain sciences · 2022Article
- Temporal variability of regional intrinsic neural activity in drug-naïve patients with obsessive-compulsive disorder.Human brain mapping · 2021Article
- Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.Neural plasticity · 2021Article
- Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder.Neural plasticity · 2021Article
- Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive-compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scan. Seed-based functional connectivity (FC) and support vector machine (SVM) were applied to analyze the imaging data. Compared with HCs, patients with OCD exhibited increased FCs between the left Crus I-left superior medial prefrontal cortex (MPFC) and between the right Crus I-left superior MPFC, left middle MPFC, and left middle temporal gyrus (MTG). A significantly negative correlation was observed between the right Crus I-left MTG connectivity and the Yale-Brown Obsessive-Compulsive Scale compulsion subscale scores in the OCD group (r = - 0.476, p = 0.002, Bonferroni corrected). SVM classification analysis indicated that a combination of the left Crus I-left superior MPFC connectivity and the right Crus I-left middle MPFC connectivity can be used to discriminate patients with OCD from HCs with a sensitivity of 85.00%, specificity of 68.42%, and accuracy of 76.92%. Our study highlights the contribution of the cerebellar-DMN connectivity in OCD pathophysiology and provides new findings to OCD research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.