ArticleNature neuroscience2019
Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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Who cites it
123 citing papers in PubMed.
- Article
- Hippocampal astrocytic sequences emerge during learning and memory recall.Nature neuroscience · 2026Article
- Microglia stabilize sleep homeostasis via adenosine AScience advances · 2026Article
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- Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis.The Journal of cell biology · 2026Article
- A developmental shift in glucocorticoid receptor expression preserves glucocorticoid sensitivity in the adult suprachiasmatic nucleus.PLoS biology · 2026Article
- Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Article
- Contribution of astrocytic calcium signaling to auditory hypersensitivity in a mouse model of fragile X syndrome.Neurobiology of disease · 2026Article
- A Low-Parameter Adaptive Framework Based on Gaussian Mixture Modeling for Detecting Weak Astrocytic Calcium Signals in Two-Photon Imaging.Bioengineering (Basel, Switzerland) · 2026Article
- Article
- AQuA2-Cloud: a web platform for fluorescence bioimaging activity analysis.bioRxiv : the preprint server for biology · 2026Article
- LPS-induced inflammation differentially affects endogenous CaMolecular medicine (Cambridge, Mass.) · 2026Article
- Article
- Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli.Journal of neurophysiology · 2026Article
- Recent optical approaches for anatomical and functional dissection of neuron-astrocyte circuitry.The Journal of physiology · 2026Review
- Real-time self-supervised denoising for high-speed fluorescence neural imaging.Nature communications · 2025Article
- Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin.Biological psychiatry · 2025Article
- Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake.PLoS biology · 2025Article
63 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
Recent work examining astrocytic physiology centers on fluorescence imaging, due to development of sensitive fluorescent indicators and observation of spatiotemporally complex calcium activity. However, the field remains hindered in characterizing these dynamics, both within single cells and at the population level, because of the insufficiency of current region-of-interest-based approaches to describe activity that is often spatially unfixed, size-varying and propagative. Here we present an analytical framework that releases astrocyte biologists from region-of-interest-based tools. The Astrocyte Quantitative Analysis (AQuA) software takes an event-based perspective to model and accurately quantify complex calcium and neurotransmitter activity in fluorescence imaging datasets. We apply AQuA to a range of ex vivo and in vivo imaging data and use physiologically relevant parameters to comprehensively describe the data. Since AQuA is data-driven and based on machine learning principles, it can be applied across model organisms, fluorescent indicators, experimental modes, and imaging resolutions and speeds, enabling researchers to elucidate fundamental neural physiology.
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