Evidence map›Paper›PMID 31570857›Full record

ArticleCell death and differentiation2020

In vivo detection of programmed cell death during mouse heart development.

Kristel Martínez-Lagunas, Yoshifumi Yamaguchi, Cora Becker, Caroline Geisen, Marco C DeRuiter, Masayuki Miura, Bernd K Fleischmann, Michael Hesse

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius).Developmental dynamics : an official publication of the American Association of Anatomists · 2025
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Kristel Martínez-LagunasInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Yoshifumi YamaguchiDepartment of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7340-4557
Cora BeckerInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Caroline GeisenInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
Marco C DeRuiterDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.
Masayuki MiuraDepartment of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7444-5705
Bernd K FleischmannInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany. bernd.fleischmann@uni-bonn.de.
Michael HesseInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany. mhesse1@uni-bonn.de.
University of Bonn · DEHokkaido University · JPLeiden University Medical Center · NLThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the great progress on the cell biology of programmed cell death (PCD), its incidence and exact time course during embryonic and particular heart development are still unclear. This is also due to the lack of models enabling to directly identify and monitor PCD cells at different time points in vivo. Herein we report generation of transgenic murine embryonic stem cell and mouse models expressing secreted Annexin V-YFP under control of the CAG promoter. This enables to visualize and quantify PCD in vitro and in vivo during embryonic development. At early embryonic stages we found Annexin V-YFP

Indexed as

ApoptosisAnimalsCaspasesEmbryo, MammalianEmbryonic DevelopmentGenes, ReporterHeartMiceMice, TransgenicMouse Embryonic Stem CellsNeural TubeOrganogenesisCaspases

Identifiers

PMID31570857
PMCPMC7205869
OpenAlexW2976782630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.