ArticleNature communications2019
A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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56citing papers in PubMed, 1 pooled it
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Epidemiology, clinical and pathological features and outcomes of listeriosis in ruminants: a systematic review and meta-analysis.The veterinary quarterly · 2025Pooled it
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- Listeria monocytogenes of two sequence types in a maternal-fetal listeriosis: clinical management and bacterial genomics.BMC infectious diseases · 2026Article
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- Fourier transform infrared spectroscopy enables rapid strain typing and cluster analysis ofFrontiers in microbiology · 2026Article
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- Dual glycosylation of wall teichoic acid modulates the O-antigen pattern and virulence in serovar 4bmLife · 2025Article
- Genomic analysis of Listeria monocytogenes diversity over a 10-year period in Uruguay.Scientific reports · 2025Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
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- The inactivated and ISA 61 VG adjuvanted vaccine enhances protection against cross-serotype Listeria monocytogenes.Veterinary research · 2025Article
- A Novel Sero-Specific-Gene Dependent Multiplex PCR Enhances the Discrimination of MajorJournal of microbiology and biotechnology · 2025Article
- Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes.Nature microbiology · 2024Article
- Deletion of glycosyltransferaseVirulence · 2024Article
- High density genomic surveillance and risk profiling of clinical Listeria monocytogenes subtypes in Germany.Genome medicine · 2024Article
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Authors and funding
24 authors at 5 institutions in 3 countries.
Yuelan YinJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China. yylan@yzu.edu.cn.ORCID http://orcid.org/0000-0003-1079-4783
Hao YaoJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-9704-0505
Swapnil DoijadInstitute of Medical Microbiology, Justus-Liebig University, Giessen, 35394, Germany.
Suwei KongJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-7377-1821
Yang ShenLaboratory of Food Microbiology, Institute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4278-1477
Xuexue CaiJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0001-9882-7070
Weijun TanJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-2595-9774
Yuting WangJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-8486-0723
Youwei FengJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0003-3376-1394
Zhiting LingJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-0079-2461
Guoliang WangJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-4464-6431
Yachen HuJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0001-6519-5839
Kai LianJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0003-0871-4123
Xinyu SunJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-7394-2301
Yuliang LiuChina Animal Disease Control Center, No.17 Tiangui Street, Daxing District, 102618, Beijing, China.ORCID http://orcid.org/0000-0002-0732-8063
Chuanbin WangChina Animal Disease Control Center, No.17 Tiangui Street, Daxing District, 102618, Beijing, China.ORCID http://orcid.org/0000-0001-7056-2314
Kuhua JiaoJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0003-1576-2270
Guoping LiuXuyi Center for Animal Disease Control and Prevention, Xuyi City, Jiangsu Province, China.ORCID http://orcid.org/0000-0003-1465-725X
Ruilong SongJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-8032-2573
Xiang ChenJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-9736-8180
Zhiming PanJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China.ORCID http://orcid.org/0000-0002-7466-872X
Martin J LoessnerLaboratory of Food Microbiology, Institute of Food, Nutrition and Health, ETH Zurich, 8092, Zurich, Switzerland.
Trinad ChakrabortyJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China. Trinad.Chakraborty@mikrobio.med.uni-giessen.de.ORCID http://orcid.org/0000-0002-1452-4759
Xin'an JiaoJiangsu Key Laboratory of Zoonosis, Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangzhou University, 48 East Wenhui Road, Yangzhou, 225009, Jiangsu Province, China. jiao@yzu.edu.cn.ORCID http://orcid.org/0000-0002-2214-3358
Jiangsu Provincial Center for Disease Control and Prevention · CNMinistry of Agriculture and Rural Affairs · CNChina Animal Disease Control Center · CNETH Zurich · CHJustus-Liebig-Universität Gießen · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The foodborne pathogen Listeria monocytogenes (Lm) is a highly heterogeneous species and currently comprises of 4 evolutionarily distinct lineages. Here, we characterize isolates from severe ovine listeriosis outbreaks that represent a hybrid sub-lineage of the major lineage II (HSL-II) and serotype 4h. HSL-II isolates are highly virulent and exhibit higher organ colonization capacities than well-characterized hypervirulent strains of Lm in an orogastric mouse infection model. The isolates harbour both the Lm Pathogenicity Island (LIPI)-1 and a truncated LIPI-2 locus, encoding sphingomyelinase (SmcL), a virulence factor required for invasion and bacterial translocation from the gut, and other non-contiguous chromosomal segments from another pathogenic species, L. ivanovii. HSL-II isolates exhibit a unique wall teichoic acid (WTA) structure essential for resistance to antimicrobial peptides, bacterial invasion and virulence. The discovery of isolates harbouring pan-species virulence genes of the genus Listeria warrants global efforts to identify further hypervirulent lineages of Lm.
Indexed as
AnimalsCaco-2 CellsGenome, BacterialGenomicsGoatsHumansListeria monocytogenesListeriosisMicePhylogenySwineVirulence
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