Evidence map›Paper›PMID 31570752›Full record

ArticleScientific reports2019

IL-12 signaling drives the differentiation and function of a T

Michael D Powell, Kaitlin A Read, Bharath K Sreekumar, Devin M Jones, Kenneth J Oestreich

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  14. T follicular helper cell development during malaria.Current opinion in immunology · 2025
    Review
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael D PowellFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Kaitlin A ReadFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Bharath K SreekumarFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Devin M JonesFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Kenneth J OestreichFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA. Ken.Oestreich@osumc.edu.
Virginia Tech · USBiomedical Research Institute · US

Funding

Identifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9M
Regulation of T helper cell differentiation by integrated STAT and Ikaros zinc finger transcription factor mechanismsR56AI127800 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2017 to 2017
$263k
NIAID NIH HHS R01 AI134972NIAID NIH HHS R56 AI127800U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI134972
6 · The paper itself

Abstract

CD4

Indexed as

Signal TransductionAnimalsCell DifferentiationFlow CytometryGene Expression RegulationInterferon-gammaInterleukin-12Interleukin-21InterleukinsMiceMice, Inbred C57BLPolymerase Chain ReactionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsInterferon-gammaInterleukin-12Interleukin-21InterleukinsStat3 protein, mouseSTAT3 Transcription FactorStat4 protein, mouseSTAT4 Transcription Factor

Identifiers

PMID31570752
PMCPMC6769002
OpenAlexW2976179804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.