ArticleScientific reports2019
Corticosteroid-Binding Globulin is expressed in the adrenal gland and its absence impairs corticosterone synthesis and secretion in a sex-dependent manner.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 23 citations in OpenAlex.
- Plasma levels of adrenaline, noradrenaline, dopamine, serotonin, and cortisol in sarcopenia: comparison with non-sarcopenic individuals and the impact of resistance exercise and nutrition interventions.Journal of the International Society of Sports Nutrition · 2025Trial
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- Binding for life: corticosteroid binding globulin from vertebrate physiology to human diseases.Frontiers in endocrinology · 2025Review
- The Impact of Dexamethasone Administration on Labor Progression in Pregnant Women: A Randomized, Double-Blind Clinical Trial.Medical journal of the Islamic Republic of Iran · 2025Article
- [The functional role and properties of transcortin in the human body].Problemy endokrinologii · 2024Review
- Potential Biomarkers to Distinguish Type 1 Myocardial Infarction in Troponin-Elevated Diseases.International journal of molecular sciences · 2023Article
- Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity.Cell proliferation · 2022Article
- Genomic and Non-Genomic Actions of Glucocorticoids on Adipose Tissue Lipid Metabolism.International journal of molecular sciences · 2021Review
- Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus.PloS one · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
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Abstract
Corticosteroid-binding globulin (CBG) is synthesized by the liver and secreted into the bloodstream where binds to glucocorticoids. Thus CBG has the role of glucocorticoid transport and free hormone control. In addition, CBG has been detected in some extrahepatic tissues without a known role. CBG-deficient mice show decreased total corticosterone levels with missing of classical sexual dimorphism, increased free corticosterone, higher adrenal gland size and altered HPA axis response to stress. Our aim was to ascertain whether CBG deficiency could affect the endocrine synthetic activity of adrenal gland and if the adrenal gland produces CBG. We determined the expression in adrenal gland of proteins involved in the cholesterol uptake and its transport to mitochondria and the main enzymes involved in the corticosterone, aldosterone and catecholamine synthesis. The results showed that CBG is synthesized in the adrenal gland. CBG-deficiency reduced the expression of ACTH receptor, SRB1 and the main genes involved in the adrenal hormones synthesis, stronger in females resulting in the loss of sexual dimorphism in corticosteroid adrenal synthesis, despite corticosterone content in adrenal glands from CBG-deficient females was similar to wildtype ones. In conclusion, these results point to an unexplored and relevant role of CBG in the adrenal gland functionality related to corticosterone production and release.
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