ArticleExperimental & molecular medicine2019
Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation.
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Article in Experimental & molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.Science advances · 2026Article
- Rising cardiovascular metabolic indices are associated with hypertension and stroke risk in individuals with abnormal glucose metabolism: A prospective cohort study.Aging clinical and experimental research · 2026Article
- From endocrine to immune: therapeutic potential of brown adipose tissue in remodelling the cardiovascular immune microenvironment.Frontiers in immunology · 2026Review
- Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium.Basic research in cardiology · 2025Article
- Exploring the nonlinear association between cardiometabolic index and hypertension in U.S. Adults: an NHANES-based study.BMC public health · 2025Article
- Effect and mechanism of Dichloroacetate in the treatment of stroke and the resolution strategy for side effect.European journal of medical research · 2025Review
- Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy.BMC pharmacology & toxicology · 2025Article
- PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration.Cell death & disease · 2024Article
- Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Identification of key genes for atherosclerosis in different arterial beds.Scientific reports · 2024Article
- The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity.Molecules (Basel, Switzerland) · 2024Review
- Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.Cardiovascular research · 2023Article
- RNA-Seq analysis of obese Pdha1Experimental animals · 2023Article
- Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine.International journal of biological sciences · 2023Review
- Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis.Heliyon · 2022Article
- Aqueous extracts of Aconite promote thermogenesis in rats with hypothermia via regulating gut microbiota and bile acid metabolism.Chinese medicine · 2021Article
- Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1Oxidative medicine and cellular longevity · 2021Article
- Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases.Journal of diabetes investigation · 2021Review
- PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.Cell death & disease · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 2 countries.
Byong-Keol Min *Department of Biomedical Science, Graduate School and BK21 plus KNU Biomedical Convergence Programs, Daegu, South Korea.
Chang Joo Oh *Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea.
Sungmi Park *Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.ORCID http://orcid.org/0000-0002-3074-5914
Ji-Min LeeDepartment of Biomedical Science, Graduate School and BK21 plus KNU Biomedical Convergence Programs, Daegu, South Korea.
Younghoon GoKorean Medicine Application Center, Korea Institute of Oriental Medicine, Daegu, South Korea.
Bo-Yoon ParkDepartment of Biomedical Science, Graduate School and BK21 plus KNU Biomedical Convergence Programs, Daegu, South Korea.
Hyeon-Ji KangResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea.
Dong Wook KimLeading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.
Jeong-Eun KimLeading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.
Eun Kyung YooLeading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.
Hui Eon KimLeading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.
Mi-Jin KimResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea.
Yong Hyun JeonLaboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea.
Yong-Hoon KimLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Chul-Ho LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.ORCID http://orcid.org/0000-0002-6996-5746
Jae-Han JeonLeading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.
In-Kyu LeeDepartment of Biomedical Science, Graduate School and BK21 plus KNU Biomedical Convergence Programs, Daegu, South Korea. leei@knu.ac.kr.
Kyungpook National University Hospital · KRKyungpook National University · KRKorea Research Institute of Bioscience and Biotechnology · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRKorea Institute of Oriental Medicine · KR
Funding
Korea Health Industry Development Institute (KHIDI) HI16C1501National Research Foundation of Korea (NRF) 2017R1A2B3006406National Research Foundation of Korea (NRF) 2017R1C1B5077060
Abstract
Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure in ApoE
Indexed as
Adipose Tissue, BrownAMP-Activated Protein KinasesAnimalsApolipoproteins EAtherosclerosisCardiovascular AgentsDichloroacetic AcidDiet, WesternDyslipidemiasEnergy MetabolismEnzyme InhibitorsFibroblast Growth FactorsGene Expression RegulationIodide PeroxidaseIodothyronine Deiodinase Type IIMaleAMP-Activated Protein KinasesApolipoproteins ECardiovascular AgentsDichloroacetic AcidEnzyme Inhibitorsfibroblast growth factor 21Fibroblast Growth FactorsIodide PeroxidaseIodothyronine Deiodinase Type IIPdk1 protein, mousePPAR alphaPpara protein, mousePyruvate Dehydrogenase Acetyl-Transferring KinaseRNA, MessengerUcp1 protein, mouseUncoupling Protein 1
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.