ArticleProceedings of the National Academy of Sciences of the United States of America2019
Laminar specific fMRI reveals directed interactions in distributed networks during language processing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 86 citations in OpenAlex.
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- The superficial layers of the primary visual cortex create a saliency map that feeds forward to the parietal cortex.PLoS biology · 2025Article
- Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.bioRxiv : the preprint server for biology · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- Closed-loop fMRI at the mesoscopic scale of columns and layers: Can we do it and why would we want to?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Dynamic layer-specific processing in the prefrontal cortex during working memory.Communications biology · 2024Article
- The neocortical infrastructure for language involves region-specific patterns of laminar gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional representation of trigeminal nociceptive input in the human periaqueductal gray.Science advances · 2024Article
- Alpha-180 spin-echo-based line-scanning method for high-resolution laminar-specific fMRI in animals.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Non-Cartesian 3D-SPARKLING vs Cartesian 3D-EPI encoding schemes for functional Magnetic Resonance Imaging at 7 Tesla.PloS one · 2024Article
- Connectivity of Fronto-Temporal Regions in Syntactic Structure Building During Speaking and Listening.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Acquisition and processing methods of whole-brain layer-fMRI VASO and BOLD: The Kenshu dataset.Aperture neuro · 2023Article
- A single case neuroimaging study of tickertape synesthesia.Scientific reports · 2023Article
- Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication.Neurosurgical review · 2023Review
- Combining arterial blood contrast with BOLD increases fMRI intracortical contrast.Human brain mapping · 2023Article
- Relating neural oscillations to laminar fMRI connectivity in visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between top-down and bottom-up information streams are integral to brain function but challenging to measure noninvasively. Laminar resolution, functional MRI (lfMRI) is sensitive to depth-dependent properties of the blood oxygen level-dependent (BOLD) response, which can be potentially related to top-down and bottom-up signal contributions. In this work, we used lfMRI to dissociate the top-down and bottom-up signal contributions to the left occipitotemporal sulcus (LOTS) during word reading. We further demonstrate that laminar resolution measurements could be used to identify condition-specific distributed networks on the basis of whole-brain connectivity patterns specific to the depth-dependent BOLD signal. The networks corresponded to top-down and bottom-up signal pathways targeting the LOTS during word reading. We show that reading increased the top-down BOLD signal observed in the deep layers of the LOTS and that this signal uniquely related to the BOLD response in other language-critical regions. These results demonstrate that lfMRI can reveal important patterns of activation that are obscured at standard resolution. In addition to differences in activation strength as a function of depth, we also show meaningful differences in the interaction between signals originating from different depths both within a region and with the rest of the brain. We thus show that lfMRI allows the noninvasive measurement of directed interaction between brain regions and is capable of resolving different connectivity patterns at submillimeter resolution, something previously considered to be exclusively in the domain of invasive recordings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.