Evidence map›Paper›PMID 31570623›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Sundaram Acharya, Arpit Mishra, Deepanjan Paul, Asgar Hussain Ansari, Mohd Azhar, Manoj Kumar, Riya Rauthan, Namrata Sharma, Meghali Aich, Dipanjali Sinha and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Mechanism of Cas9 inhibition by AcrIIA11.Nucleic acids research · 2025
    Article
  7. Article
  8. Review
  9. Rationally designedMolecular therapy. Nucleic acids · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. IDCases · 2024
    Article
  15. Evolution of CRISPR/Cas Systems for Precise Genome Editing.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sundaram AcharyaGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Arpit MishraGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Deepanjan PaulGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Asgar Hussain AnsariGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Mohd AzharGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Manoj KumarGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Riya RauthanGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Namrata SharmaGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Meghali AichGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Dipanjali SinhaGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Saumya SharmaGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Shivani JainGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Arjun RayGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Suman JainKamala Hospital and Research Centre, Thalassemia and Sickle Cell Society, Rajendra Nagar, Hyderabad, 500052, India.
Sivaprakash RamalingamGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Souvik MaitiGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India.
Debojyoti ChakrabortyGenomics and Molecular Medicine Unit, Council of Scientific and Industrial Research-Institute of Genomics & Integrative Biology, New Delhi, 110025, India; debojyoti.chakraborty@igib.in.ORCID 0000-0003-1460-7594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome editing using the CRISPR/Cas9 system has been used to make precise heritable changes in the DNA of organisms. Although the widely used

Indexed as

Gene EditingAnimalsCatalysisCRISPR-Associated Protein 9DNAFrancisellaGenomeHumansKineticsSubstrate SpecificityCas9 protein, Francisella novicidaCRISPR-Associated Protein 9DNACRISPR Cas9gene therapygenome editingiPSCssickle cell anemia

Identifiers

PMID31570623
PMCPMC6800334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.