ArticleProceedings of the National Academy of Sciences of the United States of America2019
Gradients of structure-function tethering across neocortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 294 papers.
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Who cites it
294 citing papers in PubMed.
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Structural-functional multilayer brain network properties and outcome of combined repetitive transcranial magnetic stimulation and psychotherapy for obsessive-compulsive disorder.NeuroImage. Clinical · 2026Trial
- netneurotools: a trainee-oriented approach to network neuroscience.Nature protocols · 2026Review
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Preserved intrinsic neural timescale organization with hierarchical variation in autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- Geometric constraints and cognitive inputs jointly shape emergent brain dynamics and topology.bioRxiv : the preprint server for biology · 2026Article
- A reproducible low-dimensional architecture of human white-matter connectivity.Research square · 2026Article
- Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex.Nature communications · 2026Article
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Multiscale structural connectome eigenmodes constrain human brain functional dynamics.Communications biology · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.Communications biology · 2026Article
- Structural Connectivity of Functionally Defined Episodic Memory Networks: A Large-Scale Connectome-Behavior Study.Brain and behavior · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026Article
234 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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Abstract
The white matter architecture of the brain imparts a distinct signature on neuronal coactivation patterns. Interregional projections promote synchrony among distant neuronal populations, giving rise to richly patterned functional networks. A variety of statistical, communication, and biophysical models have been proposed to study the relationship between brain structure and function, but the link is not yet known. In the present report we seek to relate the structural and functional connection profiles of individual brain areas. We apply a simple multilinear model that incorporates information about spatial proximity, routing, and diffusion between brain regions to predict their functional connectivity. We find that structure-function relationships vary markedly across the neocortex. Structure and function correspond closely in unimodal, primary sensory, and motor regions, but diverge in transmodal cortex, particularly the default mode and salience networks. The divergence between structure and function systematically follows functional and cytoarchitectonic hierarchies. Altogether, the present results demonstrate that structural and functional networks do not align uniformly across the brain, but gradually uncouple in higher-order polysensory areas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.