ArticleProceedings of the National Academy of Sciences of the United States of America2019
A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
- Comparative Genomic Screening Identifies Developmental Constraint Loci Underscoring the Phenotypic Evolution of Syngnathids.Integrative zoology · 2026Article
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Degrees of convergent evolution in rodent adaptations to arid environments.Genome research · 2026Article
- INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates.Communications biology · 2026Article
- Machine learning reveals hidden dimensions of functional similarity in proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles.Annual review of genetics · 2025Review
- Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolutionary sparse learning reveals the shared genetic basis of convergent traits.Nature communications · 2025Article
- Practical Guidance and Workflows for Identifying Fast Evolving Non-Coding Genomic Elements Using PhyloAcc.Integrative and comparative biology · 2024Article
- Molecular evolution of toothed whale genes reveals adaptations to echolocating in different environments.BMC genomics · 2024Article
- RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution.Molecular biology and evolution · 2024Article
- The case against simplistic genetic explanations of evolution.Development (Cambridge, England) · 2024Review
- Ancient developmental genes underlie evolutionary novelties in walking fish.Current biology : CB · 2024Article
- Parallel Evolution at the Regulatory Base-Pair Level Contributes to Mammalian Interspecific Differences in Polygenic Traits.Molecular biology and evolution · 2024Article
- Molecular characterization of positively selected genes contributing aquatic adaptation in marine mammals.Genes & genomics · 2024Article
- Accurate Detection of Convergent Mutations in Large Protein Alignments With ConDor.Genome biology and evolution · 2024Article
- Unraveling genomic features and phylogenomics through the analysis of three Mexican endemicPeerJ · 2024Article
- WGCCRR: a web-based tool for genome-wide screening of convergent indels and substitutions of amino acids.Bioinformatics advances · 2024Article
- RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution.bioRxiv : the preprint server for biology · 2023Article
- Genomic Basis of Freshwater Adaptation in the Palaemonid Prawn Genus Macrobrachium: Convergent Evolution Following Multiple Independent Colonization Events.Journal of molecular evolution · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Distantly related species entering similar biological niches often adapt by evolving similar morphological and physiological characters. How much genomic molecular convergence (particularly of highly constrained coding sequence) contributes to convergent phenotypic evolution, such as echolocation in bats and whales, is a long-standing fundamental question. Like others, we find that convergent amino acid substitutions are not more abundant in echolocating mammals compared to their outgroups. However, we also ask a more informative question about the genomic distribution of convergent substitutions by devising a test to determine which, if any, of more than 4,000 tissue-affecting gene sets is most statistically enriched with convergent substitutions. We find that the gene set most overrepresented (
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